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Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin

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Abstract

Nature has been used as therapeutic resources in the treatment of diseases for many years. However, some natural compounds have poor water solubility. Therefore, physicochemical strategies and technologies are necessary for development of systems for carrying these substances. The self-emulsifying drug delivery systems (SEDDS) have been used as carriers of hydrophobic compounds in order to increase the solubility and absorption, improving their bioavailability. SEDDS are constituted with a mixture of oils and surfactants which, when come into contact with an aqueous medium under mild agitation, can form emulsions. In the last years, a wide variety of self-emulsifying formulations containing bioactive compounds from natural origin has been developed. This review provides a comprehensive overview of the main excipients and natural bioactive compounds composing SEDDS. In addition, applications, new technologies and innovation are reviewed as well. Examples of self-emulsifying formulations administered in different sites are also considered for a better understanding of the use of this strategy to modify the delivery of compounds from natural origin.

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Funding

The authors acknowledge the Brazilian agencies CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/Coordination for the Improvement of Higher Education Personnel; Finance Code 001) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico/National Council of Scientific and Technological Development; Process no. 307695/2020-4) for their financial support.

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  1. Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Avenida Colombo, n. 5790, K68, S05, Maringa, Parana, 87020-900, Brazil

    Mariana Carla de Oliveira & Marcos Luciano Bruschi

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  1. Mariana Carla de Oliveira
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Correspondence to Marcos Luciano Bruschi.

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de Oliveira, M.C., Bruschi, M.L. Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin. AAPS PharmSciTech 23, 134 (2022). https://doi.org/10.1208/s12249-022-02291-z

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