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Nanostructured Lipid Carriers as a Novel Strategy for Topical Antifungal Therapy

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Abstract

Nanostructured lipid carriers (NLC) were developed as an alternative carrier system optimizing limitations found in topical treatments for superficial fungal infections, such as limited permeation through the skin. However, few published studies are focused on standardization and characterization of determinant variables of these lipid nanosystems’ quality. Thus, this systematic review aims to compile information regarding the selection of lipids, surfactants, and preparation method that intimately relates to the final quality of this nanotechnology. For this, the search was carried with the following descriptors: 'nanostructured lipid carriers', 'topical', 'antifungal' separated by the Boolean operators 'and', present in the titles of the databases: Science Direct, Scopus and Pubmed. The review included experimental articles focused on the development of nanostructured lipid carriers targeted for topical application with antifungal activity, published from 2015 to 2021. Review articles, clinical studies, and studies on the development of other nanocarriers intended for other routes of administration were excluded from the study. The research included 26 articles, of which 58% were developed in India and Brazil, 53% published in the years 2019 and 2020. As for the selection of antifungal drugs incorporated into NLCs, the azole class had a preference over other classes, voriconazole being incorporated into 5 of the 26 developed NLC studied. It was also observed a predominance of medium chain triglycerides (MCT) as a liquid lipid and polysorbate 80 as a surfactant. Among other results, this review compiles the influences of each of the variables discussed in the quality parameters of NLCs, in order to guide future research involving the development of this technology.

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Funding

This work required access to published articles which were accessed by the institutional login of the Federal University of Piauí. Therefore, this work was supported by Federal University of Piauí.

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Authors and Affiliations

  1. Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Campus Universitário Ministro Petronio Portela, Teresina, Piauí, CEP: 64049-550, Brazil

    Naiane Carvalho Nogueira & André Luis Menezes de Carvalho

  2. Hospital Universitário da Universidade Federal do Piauí, Universidade Federal do Piauí, Campus Universitário Ministro Petronio Portela, Teresina, Piauí, CEP64049-550, Brazil

    Laisa Lis Fontinele de Sá

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  1. Naiane Carvalho Nogueira
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  2. Laisa Lis Fontinele de Sá
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Manuscript’s design, planning, analysis, and writing: Naiane Carvalho Nogueira. Orientation: André Luís Menezes Carvalho. Revision and corrections: Laisa Lis Fontinele de Sá. All authors have approved the submitted final version.

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Correspondence to Naiane Carvalho Nogueira.

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Nogueira, N.C., de Sá, L.L.F. & de Carvalho, A.L.M. Nanostructured Lipid Carriers as a Novel Strategy for Topical Antifungal Therapy. AAPS PharmSciTech 23, 32 (2022). https://doi.org/10.1208/s12249-021-02181-w

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