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New Paradigms in the Treatment of Skin Infections: Lipid Nanocarriers to the Rescue

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Nanomedicine for Bioactives

Abstract

Lipid nanocarriers can be an effective drug delivery system for the treatment of skin infections by overcoming the pitfalls associated with conventional topical formulations and offer various advantages such as improved skin permeability, targeted delivery, minimal side effects, increased solubility and bioavailability. The major hurdle in current scenario is antimicrobial resistance which has led to treatment failure and high mortality. Lipid nanocarriers, in this context can be instrumental in the successful eradication of drug-resistant strains in the skin by fusing with cell membrane of infectious microbes and providing an intimate contact and delivering the anti-infective agent directly to the target site. Various lipid-based carriers include liposomes, transferosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion and nanoemulsion. This book chapter summarizes in brief the skin structure and various type of skin infections and then comprehensively describes various lipid nanocarriers and their application in the treatment of cutaneous infections.

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Acknowledgement

The author, Karan Razdan, acknowledges the Department of Science and Technology, New Delhi, India, for their financial assistance as DST INSPIRE JRF (IF170172) and is grateful to Commonwealth Scholarship Commission, UK for their support for carrying out the research work at University of Central Lancashire, UK.

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Authors and Affiliations

  1. School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston, UK

    Karan Razdan & Kamalinder K. Singh

  2. Pharmaceutics Division, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh, India

    Karan Razdan & V. R. Sinha

Authors
  1. Karan Razdan
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  2. V. R. Sinha
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  3. Kamalinder K. Singh
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Correspondence to Kamalinder K. Singh .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, SHUATS, Allahabad, Uttar Pradesh, India

    Mahfoozur Rahman

  2. Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India

    Sarwar Beg

  3. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, SHUATS, Allahabad, Uttar Pradesh, India

    Vikas Kumar

  4. Nanomedicine Research Lab, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India

    Farhan Jalees Ahmad

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Razdan, K., Sinha, V.R., Singh, K.K. (2020). New Paradigms in the Treatment of Skin Infections: Lipid Nanocarriers to the Rescue. In: Rahman, M., Beg, S., Kumar, V., Ahmad, F. (eds) Nanomedicine for Bioactives . Springer, Singapore. https://doi.org/10.1007/978-981-15-1664-1_11

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