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Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate

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Abstract

The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n-alkyl ester, through the skin. PG is an antioxidant agent; however, it seems to be a promising agent for herpis labialis treatment. Aristoflex AVC® and chitosan were used as gelling agents for nanoemulsion thickening. The developed formulations presented suitable PG content (94.4–100.3% w/w), nanometric droplet sizes (162–297 nm), high zeta potentials, and a non-Newtonian pseudoplastic behavior. Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8°C during 3 months of storage.

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Acknowledgements

The authors would like to express their grateful acknowledgments to CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and CAPES/Rede Nanobiotec (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

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Author notes

  1. Regina G. Kelmann and Mariana Colombo contributed equally to this work.

Authors and Affiliations

  1. Programa de Pós-Graduacão em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Regina G. Kelmann, Mariana Colombo & Letícia S. Koester

  2. Laboratório de Relação Estrutura-Atividade, Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil

    Ricardo J. Nunes

  3. Laboratório de Virologia Aplicada, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil

    Cláudia M. O. Simões

Authors
  1. Regina G. Kelmann
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  2. Mariana Colombo
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  3. Ricardo J. Nunes
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  4. Cláudia M. O. Simões
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  5. Letícia S. Koester
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Correspondence to Letícia S. Koester.

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Kelmann, R.G., Colombo, M., Nunes, R.J. et al. Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate. AAPS PharmSciTech 19, 2672–2678 (2018). https://doi.org/10.1208/s12249-018-1099-8

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  • DOI: https://doi.org/10.1208/s12249-018-1099-8

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