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Pectin-Based Bioadhesive Delivery of Carbenoxolone Sodium for Aphthous Ulcers in Oral Cavity

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Abstract

The objective of this study was to prepare and evaluate the pectin-based dosage form for buccal adhesion. Carbenoxolone sodium, which is used for the treatment of aphthous ulcers in oral cavity, was used as a model drug. The pectin buccal discs were prepared by direct compression. The water uptake and erosion of pectin disc increased progressively with the swelling time. The bioadhesion of dried pectin discs decreased when either the discs were hydrated or the buccal tissue was wet with a small volume of medium. The influencing factors such as pectin type, pectin to lactose ratio, and sweetener type on the formulations were investigated. The results demonstrated that buccal discs prepared from pectin with a high degree of esterification (DE) showed a weaker and more friable characteristic than that with low DE. Decreasing pectin to lactose ratio resulted in the high dissolution rate with low bioadhesive properties. Addition of sweetener in the formulations also affected the hardness, friability, and bioadhesive properties of the discs. The pectin discs containing sweetening agent showed a higher drug release than those without sweetener. The results suggested that pectin-based bioadhesive discs could be used to deliver carbenoxolone sodium in oral cavity.

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Acknowledgments

The authors wish to acknowledge the Commission of Higher Education, Thailand, and the Thailand Research Fund (TRF) for the financial support (grant number RMU4880042). NW is supported by a postdoctoral research grant from the Commission of Higher Education, Thailand. We are very pleased to acknowledge Herbstreith & Fox KG (Germany) who kindly donated the pectin samples and N. Kanawong (Paholpolphayuhasena Hospital, Thailand) who kindly supplied carbenoxolone sodium. Thanks to K. Wannalak for assistance on sample preparation.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Nathaya Wattanakorn, Panida Asavapichayont, Jurairat Nunthanid, Sontaya Limmatvapirat & Pornsak Sriamornsak

  2. Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Nathaya Wattanakorn, Panida Asavapichayont, Jurairat Nunthanid, Sontaya Limmatvapirat & Pornsak Sriamornsak

  3. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Srisagul Sungthongjeen

  4. Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand

    Doungdaw Chantasart

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  1. Nathaya Wattanakorn
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  2. Panida Asavapichayont
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  3. Jurairat Nunthanid
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  4. Sontaya Limmatvapirat
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  5. Srisagul Sungthongjeen
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  6. Doungdaw Chantasart
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  7. Pornsak Sriamornsak
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Correspondence to Pornsak Sriamornsak.

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Wattanakorn, N., Asavapichayont, P., Nunthanid, J. et al. Pectin-Based Bioadhesive Delivery of Carbenoxolone Sodium for Aphthous Ulcers in Oral Cavity. AAPS PharmSciTech 11, 743–751 (2010). https://doi.org/10.1208/s12249-010-9424-x

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  • DOI: https://doi.org/10.1208/s12249-010-9424-x

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