Abstract
The objective of this paper was to design a chewing gum formulation delivery system in situations where typical dental hygiene practice is not practical. Thus, an analog of decapeptide KSL (KSL-W), known to possess antimicrobial and antiplaque activity, was incorporated into a chewing gum formulation containing cetylpyridinium chloride (CPC). The effect of the excipients, xylitol, and peppermint oil on active ingredients in vitro release was also assessed. Gum formulations were prepared with different excipient parameters, including heating xylitol and gum base at 65 or 85°C, using ground and unground xylitol, and the addition of 1.5, 3, and 7% peppermint oil, to determine the effect of these changes on the in vitro release of KSL-W and CPC using a chewing machine. The antimicrobial and antiplaque activities of solutions released from chewed gum formulation as well as prepared standard solutions with different concentrations were tested against placebo. The optimal temperature to avoid crystallization of xylitol during preparation was 65°C. Grinding xylitol to 104.5 μm improved release of active ingredients as compared to commercially unground xylitol. Peppermint oil had opposite effects on release of KSL-W and CPC. Peppermint oil at 1.5% was determined to be suitable (91 and 88% of KSL-W and CPC released, respectively, after 40 min). The gum formulation illustrated good sustained release of KSL-W and CPC with antibacterial and antiplaque activities after chewing. An effective antimicrobial and antiplaque chewing gum formulation was developed. This formulation has the potential to overcome oral hygiene issues in those unable to follow normal dental protocols.
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Acknowledgements
This work was supported by a research grant from US Army Medical Research and Materiel Command. KPL is an employee of the US Government. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, the Department of Defense or the US Government.
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Al-Ghananeem, A.M., Leung, K.P., Faraj, J. et al. Development of a Sustained Antiplaque and Antimicrobial Chewing Gum of a Decapeptide. AAPS PharmSciTech 18, 2240–2247 (2017). https://doi.org/10.1208/s12249-016-0706-9
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DOI: https://doi.org/10.1208/s12249-016-0706-9