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Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine

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  • Theme: Rising Stars in Drug Delivery and Novel Carriers
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Abstract

The administration of cells as therapeutic agents has emerged as a novel approach to complement the use of small molecule drugs and other biologics for the treatment of numerous conditions. Although the use of cells for structural and/or functional tissue repair and regeneration provides new avenues to address increasingly complex disease processes, it also faces numerous challenges related to efficacy, safety, and translational potential. Recent advances in nanotechnology-driven cell therapies have the potential to overcome many of these issues through precise modulation of cellular behavior. Here, we describe several approaches that illustrate the use of different nanotechnologies for the optimization of cell therapies and discuss some of the obstacles that need to be overcome to allow for the widespread implementation of nanotechnology-based cell therapies in regenerative medicine.

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Acknowledgements

Some illustrations were created using biorender.com.

Funding

Funding for this work was partly provided by the New Innovator Award DP2EB028110 (NIBIB/NIH), DP1DK126199 (NIDDK/NIH), and the Lisa Dean Moseley Foundation.

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Author notes

  1. D. Alzate-Correa and W. R. Lawrence contributed equally to this work

Authors and Affiliations

  1. Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, 43210, USA

    D. Alzate-Correa, W. R. Lawrence, A. Salazar-Puerta, N. Higuita-Castro & D. Gallego-Perez

  2. Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, 43210, USA

    W. R. Lawrence

  3. Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, Ohio, 43210, USA

    N. Higuita-Castro

  4. Department of Surgery, The Ohio State University, 140 W. 19th Ave, room 3018, Columbus, Ohio, 43210, USA

    N. Higuita-Castro & D. Gallego-Perez

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  1. D. Alzate-Correa
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  2. W. R. Lawrence
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  3. A. Salazar-Puerta
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  4. N. Higuita-Castro
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Contributions

The idea was conceived by DGP, DAC, and NHC. DGP, WL, and DAC oversaw the writing and editing of the main text, with input from all co-authors. ASP oversaw the creation of figures and figure legends.

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Correspondence to D. Gallego-Perez.

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Alzate-Correa, D., Lawrence, W.R., Salazar-Puerta, A. et al. Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine. AAPS J 24, 43 (2022). https://doi.org/10.1208/s12248-022-00692-3

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