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Vitamin E Transporters in Cancer Therapy

  • Review Article
  • Theme: Transporters and Cancer Therapy
  • Published:
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Abstract

Besides their potent antioxidant activity, vitamin E isoforms demonstrated multiple therapeutic activities among which is their activity against different cancer types, including breast, prostate, and colon cancers. However, the activity of vitamin E isoforms is limited by their low bioavailability following oral administration. In addition to the low solubility, vitamin E isoforms have been established as substrates for several intestinal and hepatic transport proteins. In this review, we present reported anticancer activity of vitamin E family members and the possible utilization of vitamin E and derivatives as chemosensitizers to reverse multidrug resistance when given as part of a delivery system and/or in combination with anticancer therapeutic drugs. Then, the review discusses disposition of vitamin E members and transport proteins that play a role in determining their systemic bioavailability followed by recent advances in vitamin E formulations and delivery strategies.

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  1. Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Dr., Monroe, Louisiana, 71201, USA

    Saeed Alqahtani & Amal Kaddoumi

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  1. Saeed Alqahtani
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Correspondence to Amal Kaddoumi.

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Alqahtani, S., Kaddoumi, A. Vitamin E Transporters in Cancer Therapy. AAPS J 17, 313–322 (2015). https://doi.org/10.1208/s12248-014-9705-5

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