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On Average: Data Exploration Based on Means Can Be Misleading

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Acknowledgments

The authors gratefully acknowledge the assistance of Rachel Lin and Steven Xu.

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Authors and Affiliations

  1. Clinical Pharmacology, Advanced Modeling & Simulation, Janssen Pharmaceutical Research and Development, Beerse, Belgium

    Adrian Dunne & An Vermeulen

  2. Neuroscience, Janssen Pharmaceutical Companies of Johnson & Johnson, Titusville, New Jersey, USA

    Mila Etropolski

  3. Clinical Pharmacology, Advanced Modeling & Simulation, Janssen Pharmaceutical Research and Development, Titusville, New Jersey, USA

    Partha Nandy

Authors
  1. Adrian Dunne
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  2. Mila Etropolski
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  3. An Vermeulen
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  4. Partha Nandy
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Corresponding author

Correspondence to Adrian Dunne.

Appendix

Appendix

The following is an extract from the NONMEM® code used to fit Eq. 20 to the data.

figure a

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Dunne, A., Etropolski, M., Vermeulen, A. et al. On Average: Data Exploration Based on Means Can Be Misleading. AAPS J 14, 60–67 (2012). https://doi.org/10.1208/s12248-011-9314-5

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