Skip to main content
SpringerLink
Log in

Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation

  • Published:
AAPS PharmSci Aims and scope Submit manuscript

Abstract

The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Drennen JK, Kramer EG, Lodder RA. Advances and perspectives in near-infrared spectrophotometry. Crit Rev Anal Chem. 1991;22(6):443–475.

    Article  CAS  Google Scholar 

  2. Plugge W, van der Vlies C. The use of near-infrared spectroscopy in the quality control laboratory of the pharmacentical industry. J Pharm Biomed Anal. 1992;10(10–12):797–803.

    Article  CAS  PubMed  Google Scholar 

  3. Plugge W, van der Vlies C. Near-infrared spectroscopy as an alternative to assess compliance of ampicillin trihydrate with compendial specifications. J. Pharm Biomed Anal. 1993;11(6):435–442.

    Article  CAS  PubMed  Google Scholar 

  4. Gerhausser PCI, Kovar KA. Strategies for constructing near-infrared spectral libraries for the identification of drug substances. Appl Spectrosc. 1997;51(10):1504–1510.

    Article  CAS  Google Scholar 

  5. Derksen MWJ, van de Oetelaar PJM, Maris FA. The use of near-infrared spectroscopy in the efficient prediction of a specification for the residual moisture content of a freeze-dried product. J Pharm Biomed Anal. 1998;17:473–480.

    Article  CAS  PubMed  Google Scholar 

  6. Moretti MD, Gavini E, Peana AT. In vitro release and antiinflammatory activity of topical formulations of ketoprofen. Boll Chim Farm. 2000;139(2):67–72.

    CAS  PubMed  Google Scholar 

  7. Gurol Z, Hekimoglu S, Demirdamar R, Sumnu M. Percutaneous absorption of ketoprofen I. In vitro release and percutaneous absorption of ketoprofen from different ointment bases. Pharm Acta Helv. 1996;71(3):205–212.

    Article  CAS  PubMed  Google Scholar 

  8. Norris KH, Williams PC. Optimization of mathematical treatments of raw near-infrared signal in the measurement of protein in hard red spring wheat: I. Influence of particle size. Cereal Chem. 1984;61:158–165.

    CAS  Google Scholar 

  9. Savitzky A, Golay MJE. Smoothing and differentiation of data by simplified least squares procedures. Anal. Chem. 1964;36:1627–1639.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thermo Nicolet Corporation, 53711, Madison, WI

    Mark S. Kemper, Edgar J. Magnuson, Stephen R. Lowry & William J. McCarthy

  2. Department of Pharmaceutical Sciences, The University of Tennessee, College of Pharmacy, 38163, Memphis, TN

    Napasinee Aksornkoae, D. Christopher Watts, James R. Johnson & Atul J. Shukla

Authors
  1. Mark S. Kemper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edgar J. Magnuson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen R. Lowry
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. William J. McCarthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Napasinee Aksornkoae
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. Christopher Watts
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. James R. Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Atul J. Shukla
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark S. Kemper.

Additional information

Published: August 26 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kemper, M.S., Magnuson, E.J., Lowry, S.R. et al. Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation. AAPS PharmSci 3, 23 (2001). https://doi.org/10.1208/ps030323

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1208/ps030323

Keywords

Search

Navigation