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Fast and Convenient NIR Spectroscopy Procedure for Determination of Metformin Hydrochloride in Tablets

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Journal of Applied Spectroscopy Aims and scope

A rapid and convenient near-infrared (NIR) reflectance spectroscopic procedure for the determination of metformin hydrochloride in tablets is presented. Determination was based on calibration curves that were obtained using a range of standards containing different concentrations of metformin hydrochloride blended with polyvinylpyrrolidone. The raw spectra of the standards, neat PVP, metformin hydrochloride, and powdered tablets were processed using a Multiplicative Scatter Correction filter as well as by the derivative spectroscopy method to give a basis for the calibration curve construction. The results were validated by thin-layer chromatography followed by UV-densitometry.

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Authors and Affiliations

  1. Medical University of Lodz, ul. Muszyńskiego 1, 90-151, Lodz, Poland

    J. Pyzowski, M. Lenartowicz, A. W. Sobańska & E. Brzezińska

Authors
  1. J. Pyzowski
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  2. M. Lenartowicz
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  3. A. W. Sobańska
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  4. E. Brzezińska
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Correspondence to J. Pyzowski.

Additional information

Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 84, No. 4, p. 671, July–August, 2017.

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Pyzowski, J., Lenartowicz, M., Sobańska, A.W. et al. Fast and Convenient NIR Spectroscopy Procedure for Determination of Metformin Hydrochloride in Tablets. J Appl Spectrosc 84, 710–715 (2017). https://doi.org/10.1007/s10812-017-0534-z

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  • DOI: https://doi.org/10.1007/s10812-017-0534-z

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