Abstract
Background
Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) is listed in the World Health Organization (WHO) Classification 5th edition as a rare benign tumor with papillary growth of ciliary, goblet, and basal cells.
Case presentation
The patient was a 67-year-old female in whom a nodular shadow of 20 mm in diameter in the right lower lobe S10 center was found in chest computed tomography (CT) for examination of dorsal pain. Positron emission tomography/computed tomography (PET-CT) showed the accumulation of 18F-fluorodeoxyglucose (FDG) with a standardized uptake value (SUV)max of 13.0. Primary lung cancer was suspected, and surgery was scheduled as a therapeutic strategy. Thoracoscopic resection of the right lower lobe was performed, and possible BA/CMPT or adenocarcinoma was suggested in the differential diagnosis by the intra-perioperative rapid pathologic diagnosis. The final diagnosis was BA/CMPT. Histological findings indicated that the cause of the high FDG-PET scan might be due to many inflammatory cell infiltration in the tumor.
Conclusions
We report a resected case of BA/CMPT with exceptionally high FDG accumulation in PET.
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Discover the latest articles, news and stories from top researchers in related subjects.Introduction
Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) is a rare benign tumor included in the WHO Classification 5th edition. The tumor often develops in the peripheral lung and has a low standardized uptake value (SUV)max on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), which makes differentiation from primary lung cancer difficult. Here, we report our experience in a case of BA/CMPT that developed in the pulmonary center with high FDG accumulation in PET and was also difficult to differentiate from lung cancer.
Case presentation
The patient was a 67-year-old non-smoker female who had visited a nearby hospital for a chief complaint of dorsal pain. A suspected node in the lower lobe of the right lung was detected on chest CT, and thus, the patient was introduced to our hospital. She had comorbidities of hypertension, diabetes, and cataract and a history of cerebral hemorrhage. At the first examination, physical findings were height 153.1 cm, weight 66.8 kg, and no abnormal findings. Biochemical tests and tumor markers were normal. Respiratory function was VC 2.96 L (%VC 117.0%), FVC 2.64 L (%FVC 114.8%), FEV1 1.79 L (%FEV1 67.8%), DLCO 14.36 (%DLCO 79.2%).
Chest X-ray showed no abnormal findings in pulmonary fields, and it was difficult to identify a node (Fig. 1a). However, chest CT showed a nodular shadow with a solid region of 20 mm in diameter in the right lower lobe S10 center (Fig. 1b). Axial contrast CT of the mediastinal window showed a relatively low-density nodule with weakly heterogenous concentration (Fig. 1c). Chest CT conducted about 1 month later showed no change in the tumor size and no clear enlargement of hilar and mediastinal lymph nodes. On PET/CT, the S10 lesion in the right lower lobe showed abnormal accumulation of FDG with a SUVmax of 13.0 (Fig. 2a). In bronchoscopy performed after PET, 5 samples from biopsy of right B10a were obtained for brush cytology and lavage cytology. The diagnosis was class 2 in this cytology, but no definite diagnosis was made because lung tissue was suggested in tissue diagnosis.
Primary lung cancer could not be excluded based on these findings. Thus, the case was clinically diagnosed as primary right lung cancer (cT1cN0M0, stage 1A3), and surgery was scheduled for diagnostic therapy. Four-port thoracoscopic surgery was performed. Since the tumor was present in the pulmonary center (Fig. 2b), the right lower lobe was initially resected to allow for perioperative rapid pathologic diagnosis. To include BA/CMPT and adenocarcinoma in the differential diagnosis, mediastinal lymphadenectomy was additionally performed before completion of surgery.
Histopathologically, the tumor was diagnosed as BA/CMPT which showed mucinous nodular mass with papillary or lepidic growth of bronchiolar epithelium, including mucous, ciliated, and basal cells (Fig. 3b–d). No aggressive epithelial growth or cellular atypia was seen. Many inflammatory cells infiltrated within the tumor, including lymphocytes, neutrophils, and macrophages, suggesting subacute inflammation (Fig. 3c–d). Inflammatory cells and tumoral basal cells in the inflamed area showed immunoreactivity for Ki-67, indicating higher mitotic activity than tumoral ciliated or mucinous cells (Fig. 3e). The thoracostomy tube was removed on postoperative day (POD) 2, and the patient was discharged from hospital on POD 8. The patient is currently alive with no redevelopment in 1 year and 3 months since surgery.
a Macroscopic cut surface of the resected tumor shows a mucinous nodular lesion, measuring 20 mm in diameter in the right lower lobe of the lung (blue arrow). b Low-power view of the tumor shows abundant mucin in the alveolar spaces and papillary growth pattern, involving a bronchiole. Moderate lymphocytic infiltrate (white arrows) was observed within the tumor, often forming lymph follicles (HE stain, scale bar: 2 mm). c Representative image of inflammatory infiltrates in the tumor. There are lymphocyte-infiltrated (left part) and neutrophilic-infiltrated (right upper part) areas. Many macrophages are also observed in the alveolar spaces with mucin (lower part) (HE stain, scale bar 500 μm). d High-power view of the tumor reveal ciliated columnar cells, goblet cells, and basal cells with no atypia. Note many neutrophilic infiltrates in the epithelium and stroma (HE stain, scale bar: 100 μm). e Immunohistochemical staining of Ki-67 (MIB1) on the serial section of c. Ki-67-immunoreactivity is found on the infiltrated lymphocytes (left) and basal cells in the inflamed area (right upper). Tumoral columnar and goblet cells are mostly negative (IHC, DAB visualization, scale bar: 500 μm)
Discussion
BA/CMPT develops in the peripheral lung with mucus production and was first reported as a rare tumor, CMPT, which shows alveolus lepidic and papillary growth of biphasic ciliary, goblet, and basal cells. In 2021, the tumor was listed as bronchiolar adenoma including a nonclassical type with less papillary growth in the WHO Classification 5th edition [1]. The epidemiological characteristics of BA/CMPT include no sex difference and development at age 60 to 80 years (mean: 70.1 years) [2, 3]. Most BA/CMPT cases have been reported from Japan and other Asian countries and may involve genetic mutations of BRAF, EGFR, KRAS, HRAS, and ALK; thus, the tumor is viewed as an oncological disease [4,5,6].
CT findings for BA/CMPT show several types of frosted glass-like or solid nodes, with differences in sizes depending on the amount of mucus components in pathological findings. In a study in 16 patients with BA/CMPT, Onishi et al. found a mean nodular size of 9.1 mm, with most tumors present in the lower lobe (13/16, 81.3%) and > 50% of the tumors located close to the visceral pleura [3]. Previous findings have suggested that BA/CMPT of ≥ 15 mm in diameter is rare [7]. In FDG/PET-CT in fifteen patients with BA/CMPT, the SUVmax in 14 cases ranged from 0.57 to 1.35, with no significant increase in accumulation in most nodes. This suggests involvement of a large amount of mucus and less lymphoid infiltration [8] and makes it difficult to differentiate BA/CMPT from pulmonary adenocarcinoma in the early phase based on SUVmax alone. Based on pathological findings in our case, the abnormally high SUVmax may be due to concomitant subacute inflammation, as there was many lymphocytic and neutrophilic infiltrate within the tumor. However, primary lung cancer was strongly suspected based on preoperative examinations, as well as the large tumor size and high SUVmax, and thus, lobe resection was chosen to ensure inclusion of the tumor margin.
We used SUVmax of 2.5, which is useful for diagnosis of malignant or benign tumors, as a cutoff for BA/CMPT cases with an abnormally high SUVmax [8]. A search using “BA/CMPT, PET-CT” on database (PubMed and Ichushi Web) identified 6 cases with SUVmax ≥ 2.5 (Table 1) [9,10,11,12,13]. The tumor sizes in these cases ranged from 7 to 20 mm (mean: 14.6 mm), and all tumors were in the lower lobe. Excluding one case and our case, all were peripheral lesions. PET-CT showed FDG accumulation with SUVmax 2.7–13.0 (mean: 5.3). Most patients underwent partial resection, excluding our case. These findings suggest that most patients with high FDG accumulation have a larger tumor compared with other BA/CMPT cases, as mentioned above. Perioperative pathological diagnosis was reported in one case, in which it was difficult to differentiate the lesion from a malignant tumor, as in our case, and resection of the lung lobe was conducted. The tumor size was larger, and FDG accumulation was higher in our case than in all six previously reported cases.
Pathological diagnosis of BA/CMPT on frozen section has difficulties of differentiation from mucinous adenocarcinoma and mucous cell metaplasia. BA/CMPT has fewer atypical mucous cells, the presence of ciliary cells, and biphasic bronchoepithelial cells and basal cells, as important characteristics [14]. Shirsat et al. found that only 16.7% (3/18) cases of CMPT could be diagnosed using operative rapid pathologic diagnosis alone. In most cases, CMPT was underrecognized and misdiagnosed as primary lung adenocarcinoma, and this may result in unnecessary treatment [15]. Frozen diagnosis has limitation of the quantity and quality of sample; thus, surgeons should know the limitation of diagnostic accuracy. For the accurate diagnosis, surgeons and pathologists should share the patient’s information, including radiological findings and clinical course. If a sufficient surgical margin can be ensured in surgery for BA/CMPT, radical cure is possible, and no redevelopment and metastasis have been reported to date. Limited surgery should be selected, and segmentectomy and lung lobectomy are not needed, other than for securing the stump. As mentioned above, rapid diagnosis is difficult, and care should be taken to avoid an erroneous diagnosis of mucinous adenocarcinoma.
Since our case had a large tumor and an abnormally high SUVmax, primary lung cancer was strongly suspected. Furthermore, the tumor developed in the pulmonary center, and thus, lobectomy was appropriate. A search for “BA/CMPT, pulmonary center” in PubMed/Ichushi Web identified four cases (Table 2) [16,17,18,19]. The tumor size and FDG accumulation in our case were larger than those in the four previous cases. Lobe resection was selected for the pulmonary center lesions in all five cases. This reflects the difficulty of ensuring the margin using partial or segmental resection for lesions in this location, and thus, lobectomy is performed. However, care is required to differentiate cases with high FDG accumulation from primary lung cancer. Thus, it is important to diagnose and treat patients with a pulmonary tumor with inclusion of BA/CMPT in differential diagnosis before surgery.
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We are grateful to the laboratory staff of the Department of Pathology for their technical assistance.
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NY, conception and design and acquisition of data; TH, conception and design and been involved in drafting the manuscript or revising it critically for important intellectual content; NM, conception and design, analysis and interpretation of data, and revising it critically for important intellectual content; TI, conception and design, analysis, and interpretation of data; SK, revising it critically for important intellectual content; YY, revising it critically for important intellectual content; YN, revising it critically for important intellectual content; HK, revising it critically for important intellectual content; and HA, revising it critically for important intellectual content. All authors read and approved the final manuscript.
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Yamashita, N., Hirata, T., Motoi, N. et al. A case of bronchiolar adenoma/ciliated muconodular papillary tumor in the pulmonary center with high FDG accumulation on PET. Gen Thorac Cardiovasc Surg Cases 2, 37 (2023). https://doi.org/10.1186/s44215-023-00052-3
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DOI: https://doi.org/10.1186/s44215-023-00052-3