Abstract
The Inari ClotTriever system (Inari Medical, Irvine, California) is safe and effective for the treatment of DVT. However, because it consists of a 31 cm coring device and collection bag that must be extended for use, application may be precluded by available intravascular “running room”, such as in the presence of an IVC filter. Here we present a technique for bypassing IVC filters via retrograde deployment of the ClotTriever within a sheath, as illustrated in three cases. This technique extends the applicability of the ClotTriever to locations in which its length would otherwise preclude use.
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Background
The Inari ClotTriever system (Inari Medical, Irvine, California) is safe and effective for the treatment of DVT [1, 2]. However, because it consists of a 31 cm coring element and collection bag that must be extended for use, application may be precluded by available intravascular “running room”. One scenario in which this limitation presents itself is in the presence of an IVC filter, which could catch on the device. Here we present a technique for bypassing IVC filters via retrograde deployment of the ClotTriever within a sheath, as illustrated in three cases. IRB exemption was granted for this series.
Results
Case 1
An 84-year-old woman who underwent meningioma resection 20 years prior preceded by prophylactic placement of a Bird’s Nest filter (Cook Medical, Bloomington, Indiana) presented with bilateral lower extremity edema and was found to have occlusive thrombus extending from the filter into the bilateral popliteal veins (Fig. 1a). Systemic thrombolysis was felt to be high risk given her age, so mechanical thrombectomy was performed. With the patient supine, a 14 French sheath was introduced in the right internal jugular vein (IJV) and a suprarenal filter placed as embolic protection. An AngioJet catheter (Boston Scientific, Marlborough, Massachusetts) was then used to infuse 10 mg of tissue plasminogen activator into the IVC and both lower extremities. The patient was then repositioned prone and 16 French ClotTriever sheaths placed in both popliteal veins. After achieving through-and-through access, the IJ sheath was advanced below the level of the filter. The ClotTriever was then sequentially introduced through each popliteal vein and advanced into the IJ sheath, deployed with the coring element just outside of the sheath and the collection bag within it, and then retracted toward the popliteal access site (Fig. 1b). After reestablishing patency and dilating the central deep veins, iliocaval stenting was performed.
Case 2
A 75-year-old woman with breast cancer, malignant gastrointestinal stromal tumor, and prior venous thromboembolism on Lovenox presented with a headache and was found to have hemorrhagic right dural metastases. Anticoagulation was discontinued and an infrarenal IVC filter placed. Three months later she presented with right lower extremity edema and was found to have DVT extending from the filter through the popliteal vein on the right and the superficial femoral vein on the left. Thrombolytics were contraindicated given her age and intracranial metastases, so mechanical thrombectomy was performed. With the patient supine, a suprarenal filter was placed as embolic protection. Then, with the patient prone, a 12 French sheath was placed in the left popliteal vein and a 13 French ClotTriever sheath in the right. A Glidewire Advantage guidewire (Terumo, Shibuya, Tokyo, Japan) was snared from the right popliteal sheath out the left, establishing through-and-through access. The ClotTriever device was then introduced through the right popliteal sheath into the left popliteal sheath and deployed (Fig. 2a). Multiple passes were then made, reestablishing patency of the lower extremity deep veins (Fig. 2b). Thrombus was removed from the filter using a FlowTriever catheter (Inari), after which angioplasty and iliocaval stenting were performed.
Case 3
A 34-year-old male with Factor V Leiden, recurrent DVT despite anticoagulation, and an indwelling fractured TRAPEASE IVC filter (Cordism Hialeah, Florida) who had undergone multiple prior thrombectomies presented with shortness of breath and lower extremity swelling. He was found to have subsegmental pulmonary emboli and thrombus extending from the filter through both lower extremities, so mechanical thrombectomy was performed. With the patient supine, a 20 French Protrieve sheath (Inari) was introduced into the right IJV to act as embolic protection. A 16 French ClotTriever sheath (Inari) was placed in the left popliteal vein and through-and-through wire access obtained. A 12 French sheath was then introduced coaxially through the Protrieve sheath and advanced until the tip was caudal to the filter. The ClotTriever was then advanced via the popliteal access into it the 12 French sheath, deployed, and mechanical thrombectomy performed (Fig. 3a, b). Additional thrombus was removed from the IVC and right leg with a FlowTriever aspiration catheter (Inari), after which a stent was placed across the fractured filter. A retrievable IVC filter was then placed in a suprarenal position.
Conclusions
ClotTriever use is limited by the length of the collection basket, which requires adequate room for extension. As shown here, additional length can be generated through introduction of a sheath at the far end of the device, into which the basket can be advanced. The sheath must be a minimum of 12 French and is most effective when through-and-through wire access is present. Although the Protrieve sheath is large enough to accommodate the basket, the sheath funnel can become entangled with it and so should only be used with a coaxial sheath present. In conclusion, the reverse sheathing technique extends the applicability of the ClotTriever to locations in which its length would otherwise preclude use.
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References
Chan SM, Laage Gaupp FM, Mojibian H. ClotTriever system for mechanical thrombectomy of deep vein thrombosis. Futur Cardiol. 2023;19(1):29–38.
Dexter DJ, Kado H, Schor J, Annambhotla S, Olivieri B, Mojibian H, et al. Interim outcomes of mechanical thrombectomy for deep vein thrombosis from the all-comer CLOUT registry. J Vasc Surg Venous Lymphat Disord. 2022;10(4):832–40 e2.
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JCH: Manuscript conception and preparation. AM: Manuscript preparation. HM: Manuscript conception and preparation.
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IRB exemption was granted for this retrospective series.
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JCH: Payment for a single lecture from Inari Medical.
AM: Consulting fees from Inari Medical; Payments for lectures, educational events, and presentations from Inari Medical.
HM: Grants or contracts from Inari Medical; Consulting fees from Inari Medical; Support for attending meetings and/or travel from Inari Medical; Stock or stock options from AlykaHealth and AIDOC.
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Cornman-Homonoff, J., Marino, A.G. & Mojibian, H. Reverse sheathing technique for iliocaval thrombectomy in the setting of IVC filters. CVIR Endovasc 7, 21 (2024). https://doi.org/10.1186/s42155-024-00437-7
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DOI: https://doi.org/10.1186/s42155-024-00437-7