Correction : Stem Cell Research & Therapy (2021) 12:15 https://doi.org/10.1186/s13287-020-02070-2
Following the publication of this article, the authors regretfully found one errors in the article and would like to make corrections:
The word “PI” mentioned in the article was wrongly described and should be changed to “Cleaved PARP (Asp214)”. PARP has been reported to cleave when cells undergo apoptosis or necrosis in previous studies. Thus, cleavage analysis of this specific protein can be a sensitive tool to detect apoptosis or necrosis. However, the datasheet of Cleaved PARP (Asp214) kit indicated the cleaved PARP serves as a marker of apoptosis. To clear up this confusion, in the Materials and methods section, “TUNEL and PI assay” should be corrected to “TUNEL and Cleaved PARP (Asp214) assay”, “Cell apoptosis and death in the liver were measured using the one-step TUNEL Apoptosis Assay kit and propidium iodide (PI) staining (Beyotime Biotechnology, Shanghai, China) according to the manufacturer’s instructions” should be corrected to “Cell apoptosis in the liver were measured using the one-step TUNEL Apoptosis Assay kit and Cleaved PARP (Asp214) (Cell Signaling Technology, #94885) according to the manufacturer’s instructions”. In the Results section, “TUNEL and PI staining confirmed the hepatocyte necrosis and apoptosis were decreased when infused with MSC, especially in the MSC-COX2(+) group; however, MSC-COX2(−) failed to decrease hepatocyte necrosis and apoptosis (Fig. 1c, d)” should be corrected to “TUNEL and Cleaved PARP (Asp214) staining confirmed the hepatocyte apoptosis were decreased when infused with MSC, especially in the MSC-COX2(+) group; however, MSC-COX2(−) failed to decrease hepatocyte apoptosis (Fig. 1c, d)”.
Specifically, we want to make the following changes:
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1.
Figure 1: in Figure 1d the label of the immunofluorescence staining is mislabeled, which should be Cleaved PARP (Asp214)/DAPI; in the figure legend, change “Representative images of PI staining to indicate necrosis cells and the number of PI-positive cells in each group” to “Representative images of Cleaved PARP (Asp214) staining to indicate apoptosis cells and the number of Cleaved PARP (Asp214) -positive cells in each group”.
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Figure 2: in Figure 2f the western blots band of c-Jun was wrongly used. The correct image has been replaced.
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Figure 7: in Figure 7c the western blots band of p-TAK1 (Ser439) was wrongly used. The correct image has been replaced.
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4.
Page 4, left column, lines 10, change “Fig. 2e” to “Fig. 2f”.
The corrected figures:
These corrections will not affect the result and conclusion of the article. We sincerely apologize for any inconvenience caused.
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Wang, J., Liu, Y., Ding, H. et al. Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization. Stem Cell Res Ther 14, 338 (2023). https://doi.org/10.1186/s13287-023-03570-7
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DOI: https://doi.org/10.1186/s13287-023-03570-7