Retraction Note: Alz Res Ther 13, 37 (2021)
https://doi.org/10.1186/s13195-021-00769-9
The Editors-in-Chief have retracted this article at the authors' request. After publication, concerns were raised regarding a number of cases of image overlap within the Figures, which the authors addressed by a Correction [1]. However, subsequent concerns have been raised about further image similarities within the article, as well as with previous studies. Specifically:
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Fig. 3b 5xFAD + Veh CAI 12-month-old group image appears highly similar to an image representing the same group in [2].
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In Fig. 3B, 5xFAD + SCLP Cortex and Entorhinal cortex images appear to originate from the same sample.
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In Fig. 3E, the beta-tubulin blots presented for the cortex 6- and 12-month-old groups appear highly similar; the beta-tubulin blot image for hippocampus in the 6-month-old group appears highly similar to that representing beta-tubulin in the 12-month-old group in Figs. 5F and 7A.
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The updated Fig. 4G 5xFAD Primary 6-month-old group image appears to overlap with Fig. 4I 5xFAD Secondary 12-month-old group.
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The top beta-tubulin blot in Fig. 6F appears highly similar to the beta-tubulin (hippocampus) blot in Fig. 7A.
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The blots in Fig. S2I appear highly similar to those in Fig. 3D of [3, now retracted].
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Fig. S5A appears highly similar to the Merged 5xFAR + SLCP (2d) image in Fig. 1B of [3, now retracted].
Despite internal data validation, the authors no longer have sufficient confidence in the findings of this study.
All authors agree to this retraction.
References
Maiti P, Bowers Z, Bourcier-Schultz A, et al. Correction to: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis. Alz Res Ther. 2022;14:42. https://doi.org/10.1186/s13195-022-00980-2.
Maiti P, Manna J, Burch ZN, et al. Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer’s Disease. Int J Mol Sci. 2020;21(18):6664. https://doi.org/10.3390/ijms21186664.
Maiti P, Paladugu L, Dunbar GL. RETRACTED ARTICLE: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease. BMC Neurosci. 2018;19:7. https://doi.org/10.1186/s12868-018-0406-3.
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Maiti, P., Bowers, Z., Bourcier-Schultz, A. et al. Retraction Note: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis. Alz Res Therapy 15, 162 (2023). https://doi.org/10.1186/s13195-023-01313-7
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DOI: https://doi.org/10.1186/s13195-023-01313-7