Correction to: Alz Res Therapy 13, 140 (2021)
https://doi.org/10.1186/s13195-021-00884-7
Following the publication of the original article [1] the authors noticed that the published Fig. 3 is incorrect. The original article [1] has been updated.
Below is the correct Fig. 3.
Modelling APOE separately, assuming the same effect of APOE-ε4 (OR ~ 3) in all age groups, and accounting for age related differences in frequency of APOE-ε4 allele (MAF = 0.18 in 55+ and MAF = 0.05 in 85+). In age group 65+ (left) the presence of APOE-ɛ4 allele increases the AD probability from 0.01 to 0.07 when PRS is the lowest and from 0.2 to 0.66 when the PRS is highest (top vs bottom lines). For 85+ age group (right), these values are 0.06 to 0.3 (low PRS) and 0.65 to 0.92 (high PRS)
Reference
Escott-Price V, Schmidt KM. Probability of Alzheimer’s disease based on common and rare genetic variants. Alz Res Therapy. 2021;13(1):140. https://doi.org/10.1186/s13195-021-00884-7.
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Escott-Price, V., Schmidt, K.M. Correction to: Probability of Alzheimer’s disease based on common and rare genetic variants. Alz Res Therapy 13, 156 (2021). https://doi.org/10.1186/s13195-021-00898-1
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DOI: https://doi.org/10.1186/s13195-021-00898-1