Correction: J Exp Clin Cancer Res 40, 157 (2021)
Following the publication of the original article [1], authors would like to correct he typographical error in the cell line under Materials and Methods, Cell Culture section.
The correct sentence should read as:
Two human MTC cell lines (TT, MZ-CRC-1), and one normal human thyrocyte cell line (NThy-ori3.1) were used for the study as TT and MZ-CRC-1 are the two of most widely used MTC-derived cell lines [23–25].
Furthermore, the figure legends for figure 1, 3, 5 and 6 are in the wrong order. The right order for these figure legends are given below:
Fig. 1 miR-455-5p was reduced in MTC and overexpression of miR-455-5p suppressed MTC cell proliferation, migration, and invasion. a Relative miR-455-5p levels in MTC tissues and adjacent non-tumor tissues. b Survival rate in patients with high miR-455-5p level and low miR-455-5p level. c Relative miR-455-5p levels in MTC cells. d Relative miR-455-5p levels in MTC cells transfected with mimics NC or miR-455-5p mimics. e & f Representative images of colonies formed in mimics NC transfected or miR-455-5p mimics transfected MTC cells. g Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. h Flow cytometry analysis of cell apoptosis in MTC cells transfected with mimics NC or miR-455-5p mimics. i & j Transwell assay to quantify the migration and invasion abilities of transfected cells. k & l EMT-related protein levels in transfected MTC cells. *P < 0.05; ** P < 0.01;*** P < 0.001
Fig. 3 Inhibition of CXCL12/CXCR4 signaling blocked the effects of miR-455-5p inhibitor on MTC cell proliferation, migration, and invasion. a Relative CXCL12 mRNA and protein levels in MTC cells transfected shNC or shCXCL12. b & c Representative images of colonies formed in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. d Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. e Flow cytometry analysis of cell apoptosis in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. f & g Transwell assay to analyze the migration and invasion abilities of transfected cells. h & i EMT-related protein levels in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. *P < 0.05; ** P < 0.01; *** P < 0.001
Fig. 5 Knockdown of circPVT1 suppressed MTC cell proliferation, migration, and invasion. a & b The number of colonies formed in shNC transfected or shcircPVT1 transfected MTC cells. c Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. d Flow cytometry analysis of cell apoptosis in MTC cells transfected with shNC or shcircPVT1. e & f Transwell assay assay to analyze migration and invasion abilities of transfected cells. g & h EMT-related protein levels in MTC cells transfected with shNC or shcircPVT1. * P < 0.05; ** P < 0.01; *** P < 0.001
Fig. 6 ci rcPVT1 regulated MTC cells proliferation and apoptosis via miR-455-5p/CXCL12 axis. a Relative circPVT1 level in MTC cells transfected circPVT1 overexpressing vector. b & c The number of colonies formed in MTC cells transfected with circPVT1 overexpressing vector or miR-455-5p mimics or treated with CXCR4 antagonist AMD3100. d Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. e Flow cytometry analysis of cell apoptosis in MTC cells transfected with circPVT1 overexpressing vector or miR-455-5p mimics or treated with CXCR4 antagonist AMD3100. * P < 0.05; ** P < 0.01; *** P < 0.001
These corrections do not affect the overall result or conclusion of the article. The original article has been corrected.
References
Zheng X, Rui S, Wang XF, et al. circPVT1 regulates medullary thyroid cancer growth and Metastasis by targeting mir-455-5p to activate CXCL12/CXCR4 signaling. J Exp Clin Cancer Res. 2021;40:157. https://doi.org/10.1186/s13046-021-01964-0.
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Zheng, X., Rui, S., Wang, XF. et al. Correction: circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling. J Exp Clin Cancer Res 42, 299 (2023). https://doi.org/10.1186/s13046-023-02880-1
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DOI: https://doi.org/10.1186/s13046-023-02880-1