Retraction Note: J Exp Clin Cancer Res 37, 284 (2018)
https://doi.org/10.1186/s13046-018-0956-3
The Editor-in-Chief has retracted this article at the request of the authors. After publication, concerns were raised about the data presented in Fig. 8c having been published elsewhere representing different samples [1,2,3,4,5]. The authors checked their data and noticed that inaccurate results were presented in Fig. 1B, 3F and 5E. Further investigation revealed the following additional issues:
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In Fig. 4D, the background of parts of the Flag bands appears completely smooth, as if parts of the image have been removed.
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In Fig. 5E (right panel), there is a noticeable break in the background of the blot, and the two parts are misaligned in the image.
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In Fig. 6C,
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○ the image of the bands presented for MNAT1 (LoVo cells) appears highly similar to that in Fig. 2D DLD1 cells;
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○ MDM2 and MNAT1 and HSP60 (HEK293T cells) appear highly similar to Fig. 2A MNAT1 and GAPDH (HCT116 cells);
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○ p53 (LoVo cells) bands apprat highly similar to those presented for MNAT1 in Fig. 6D.
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In Fig. 7A, the GAPDH bands appear highly similar to the HSP70 bands in Fig. 3A-b.
The data reported in this article are therefore unreliable. In addition, the authors were unable to provide a copy of the original Ethics Approval for the animal study upon the Editor's request, which raises further concerns about the integrity of the article.
None of the authors have responded to any correspondence from the editor or publisher about this retraction.
References
Tang F, Wang D, Duan C, et al. Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567. J Biol Chem. 2009;284(40):27456–66. https://doi.org/10.1074/jbc.M109.033795.
Huang D, Li Y, Liu N, et al. Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics. BMC Cancer. 2014;14:243. https://doi.org/10.1186/1471-2407-14-243.
Tan G, Tang X, Huang D, Li Y, Liu N, Peng Z, et al. Dinitrosopiperazine-mediated phosphorylated-proteins are involved in nasopharyngeal carcinoma metastasis. International Journal of Molecular Sciences. 2014;15:20054–71.
Peng Z, Liu N, Huang D, Duan C, Li Y, Tang X, et al. N,N'-dinitrosopiperazine–mediated heat-shock protein 70-2 expression is involved in metastasis of nasopharyngeal carcinoma. PLoS ONE. 2013;8(5):e62908. https://doi.org/10.1371/journal.pone.0062908.
Tang F, Zou F, Peng Z, et al. N,N'-dinitrosopiperazine-mediated ezrin protein phosphorylation via activation of Rho kinase and protein kinase C is involved in metastasis of nasopharyngeal carcinoma 6-10B cells. J Biol Chem. 2011;286(42):36956–67. https://doi.org/10.1074/jbc.M111.259234.
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Zhou, S., Lu, J., Li, Y. et al. Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance. J Exp Clin Cancer Res 40, 401 (2021). https://doi.org/10.1186/s13046-021-02204-1
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DOI: https://doi.org/10.1186/s13046-021-02204-1