Abstract
Background
Aorto-ventricular tunnel (AVT) is an abnormal communication channel between the ascending aorta and the ventricle. It commonly has two orifices, i.e., one aortic opening and one ventricular opening. In this study, we present a unique case of AVT with three orifices: one aortic opening, one LV opening, and one RV opening.
Case presentation
A 64-year-old male presented with chest discomfort and dyspnea on exertion lasting the past six months. Physical examination revealed a grade 4/6 continuous biphasic murmur along the left sternal edge and a grade 3/6 systolic murmur at the apex. Transthoracic echocardiography (TTE) demonstrated: (1) an AVT with three orifices, i.e., one aortic opening, one LV opening, and one RV opening. The LV and RV openings were located in the left and right ventricular outflow tracts, respectively. (2) The aortic valve (AV) was calcified with a small aneurysm at the non-coronary cusp. (3)The mitral valve (MV) chordal rupture of the P2 and P3 segments was observed in the posterior leaflet with severe eccentric regurgitation. Subsequent coronary computed tomography angiography (CTA) further confirmed the diagnosis of AVT with three openings, and clarified the coronary arteries normally arose from the aortic sinuses. The patient was then referred for surgical treatment, consisting of closure of three AVT orifices, AV replacement, and MV replacement. Six months following surgery, the patient was asymptomatic. TTE demonstrated normal mechanic AV and MV function, and there was no residual shunt among the ascending aorta, LV and RV.
Conclusions
It is the first case to report an AVT with three orifices. This paper described the entire process from diagnosis to treatment of this unique case, thus providing some novel insights into AVT.
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Find the latest articles, discoveries, and news in related topics.Background
Aorto-ventricular tunnel (AVT) is an abnormal communication channel between the ascending aorta and the ventricle. It commonly has two orifices, i.e., one aortic opening and one ventricular opening. The aortic opening usually lies above the right coronary sinus and rarely above the left and non-coronary sinus, while the ventricular opening can be in the left ventricle (LV) or right ventricle (RV) but is mainly located in the left/right ventricular outflow tract [1].
AVT is a rare congenital heart defect first described in 1963 by Levy et al. [2]. Since then, approximately 250 cases of the aorto-left ventricular tunnel (ALVT) and 30 cases of aorto-right ventricular tunnel (ARVT) have been reported in the English literature. In this paper, we presented a unique case of AVT with three orifices, i.e., one aortic opening, one LV opening, and one RV opening (Fig. 1). To the best of our knowledge, no such cases have been reported in the English literature so far.
Case presentation
A 64-year-old male presented with chest discomfort and dyspnea on exertion lasting the past six months. His past medical history was unremarkable. Physical examination revealed a grade 4/6 continuous biphasic murmur along the left sternal edge and a grade 3/6 systolic murmur at the apex. His blood pressure was 124/66 mmHg, and his heart rate was 86 beats/min. The patient had no Marfan traits, and the electrocardiogram (ECG) showed atrial fibrillation, ventricular premature, left ventricular hypertrophy, and ST-T wave abnormalities (Fig. 2). Transthoracic echocardiography (TTE) demonstrated: (1) An enlarged heart with a reduced left ventricular ejection fraction of 42%. (2) An AVT was noted, and its aortic and LV opening was observed in the parasternal long-axis view (Fig. 3A, Video 1). Color Doppler flow imaging (CDFI) revealed the anterograde systolic and retrograde diastolic flow between the aorta and the LV via the AVT in the parasternal long-axis view (Fig. 3B-C, Video 2). The retrograde diastolic flow via the AVT was also shown in the apical five-chamber view (Fig. 3D, Video 3). (3) With a slight tilt of the probe, an RV opening was observed from the AVT in the modified parasternal long-axis view, and CDFI displayed a flow jet from the AVT to the RV (Fig. 3E-F, Videos 4 and 5). The RV opening was also confirmed in the short-axis view (Fig. 3G-H, Videos 6 and 7), and a biphasic spectrum was detected at the RV opening with a peak velocity of 489 cm/s. (4) The aortic valve (AV) was calcified with a small aneurysm of the non-coronary cusp (Fig. 3I). (5) The mitral valve (MV) chordal rupture of the P2 and P3 segments was observed in the posterior leaflet with severe eccentric regurgitation (Fig. 3J-L). Detailed cardiac measurement parameters are shown in Table 1.
TTE images. A An AVT was noted, and its aortic and LV opening was observed in the parasternal long-axis view. B-C Color Doppler flow imaging (CDFI) revealed the anterograde systolic and retrograde diastolic flow between the aorta and the LV via the AVT in the parasternal long-axis view. D The retrograde diastolic flow via the AVT was also shown in the apical five-chamber view. E–F With a slight tilt of the probe, an RV opening was observed from the AVT in the modified parasternal long-axis view, and CDFI displayed a flow jet from the AVT to the RV. G-H The RV opening was also confirmed in the short-axis view. I The AV was calcified with a small aneurysm of the non-coronary cusp. J-L The MV chordal rupture of the P2 and P3 segments was observed in the posterior leaflet with severe eccentric regurgitation
Computed tomography angiography (CTA) revealed: (1) both coronary arteries normally arose from the aortic sinuses (Fig. 4A-B); (2) An AVT is anteriorly and laterally located to the right coronary sinus (Fig. 4C); (3) The LV opening was in the LV outflow tract (Fig. 4D); (4) The RV opening was in the RV outflow tract (Fig. 4E). With 3D reconstruction, the AVT and its RV opening were shown intuitively (Fig. 4F-G). Coronary artery angiography (CAG) further confirmed that coronary arteries originated normally arose from the aortic sinuses and revealed complete perfusion of grade 3 TIMI blood flow (Fig. 5A-B).
CTA images. A Origin of the LCA (arrow) from the left coronary sinus. B Origin of the RCA (arrow) from the right coronary sinus. C An AVT (asterisk) is anteriorly and laterally located to the right coronary sinus. D The LV opening (arrow) of the AVT was in the left ventricular outflow tract. E The RV opening (arrow) of the AVT was in the right ventricular outflow tract. F The AVT (arrow) was shown by 3D reconstruction. G The RV opening (arrow) was shown by 3D reconstruction
Laboratory analysis showed a mildly elevated N-terminal pro-brain natriuretic peptide (NT-pro-BNP) of 641 pg. Other laboratory tests were within normal reference ranges, such as complete blood count, serum electrolytes, coagulation function, hepatic function, renal function, autoimmune markers, and inflammatory markers. The main parameters of the laboratory test could be obtained from the supplementary Table S1.
The patient subsequently underwent surgery. At operation, the AVT with three orifices was confirmed. The aortic opening was above the right coronary sinus, the LV opening was in the LV outflow tract, and the RV opening was in the RV outflow tract. The nerve retractor could detect the LV and RV openings from the aortic opening (Fig. 6A). The AV was tricuspid with areas of calcification and a small aneurysm at the non-coronary cusp (Fig. 6B). There was evidence of chordal rupture of the P2 and P3 segments of the MV posterior leaflet (Fig. 6C). AVT was repaired with a 5–0 Prolene suture with pledgets to close the aortic opening and 4–0 Prolene with a pericardial patch to close the LV and RV opening. Due to calcification and dysfunction, the AV was replaced with a bileaflet mechanical valve (23 mm, St. Jude regent, USA). Considering that the patient was elderly with a significantly enlarged LV, the MV was replaced with a bileaflet mechanical valve (27 mm, Sorin Biomedica, Italy) instead of mitral repair.
Intraoperative images. A The aortic opening was above the right coronary sinus, the LV opening was in the LV outflow tract, and the RV opening was in the RV outflow tract. The nerve retractor could detect the LV and RV openings from the aortic opening. B The AV was tricuspid with areas of calcification and a small aneurysm at the non-coronary cusp. C The MV chordal rupture of the P2 and P3 segments was observed in the posterior leaflet
Microscopic pathologic examination of the excised AV and MV revealed fibrosis, hyalinization, and areas of necrosis and calcification. The postoperative recovery was uneventful. Six months later, the patient was asymptomatic. TTE demonstrated normal mechanic AV and MV function, and there was no residual shunt among the ascending aorta, LV and RV. The systolic function of both ventricles was normal.
Discussion and conclusions
AVT is a rare congenital cardiac malformation characterized by abnormal communication between the ascending aorta and the ventricle. The incidence of ALVT ranges between 0.001% and 0.1% of all postnatal congenital heart defects but is much higher in prenatal heart specimens, reaching 0.5% [3,4,5]. The ARVT is rarer, with about one-eighth of the AVT communicating with the RV [6]. AVT commonly has two orifices, i.e., aortic opening and ventricular opening. There are no previous reports on AVT with three orifices. This paper presented a peculiar and unique case of AVT with one aortic opening, one LV opening, and one RV opening. The patient had never taken an echocardiographic assessment, so it is hard to say whether the RV opening is congenital or acquired. If it is congenital, it could be termed an “aorto-biventricular tunnel.” However, it is possible that the RV opening was spontaneous rupture due to the shear stress caused by the long-term shunt of the ALVT, and if this was the case, such a condition could be termed “ALVT with a breach to the RV.”
AVT often presents during infancy or early childhood as cardiac failure symptoms or an incidental finding of a cardiac murmur. Some patients are asymptomatic or have minimal symptoms; therefore, they are not diagnosed until adulthood [7, 8]. The patient we reported on in the present study is one such case. AVT may occur as an isolated lesion or associated with other cardiac diseases. AV lesions are most frequent in association, ranging from bicuspid valves without obstruction to dysplasia and even atresia. However, their association with AV aneurysm and MV chordal rupture has not yet been reported. AV aneurysm is sporadic and often associated with infective endocarditis [9]. The common causes of MV chordal rupture are degeneration and infective endocarditis. There was no typical evidence, such as fever, positive blood culture, and vegetation, to support infective endocarditis in this case. However, it was still not possible to rule out that the AV and MV lesions resulted from infective endocarditis. In addition, long-term turbulence caused by AVT could also result in an AV aneurysm, and degeneration may cause the MV chordal rupture.
The differential diagnosis of the AVT includes ventricular septal defect and rupture of the sinus of Valsalva. In the present study, we did not consider the ventricular septal defect because: (1) the flow shunt was not directly from the LV to the RV; (2) the spectrum was not only in the systolic period. The ruptured sinus of Valsalva was also not considered because (1) the ruptured sinus of Valsalva mainly occurs in aneurysmal dilated sinuses, which did not happen in our case; (2) there is no tunnel in the ruptured sinus of Valsalva, which did exist in our case.
Once the diagnosis of AVT is established, AVT closure should be performed as soon as possible. Although there are case reports of percutaneous device closure of the defect [10, 11], surgical correction is considered the optimal and standard treatment strategy. Moreover, the patch closure of each orifice is recommended [12, 13]. Our case received surgical closure for three openings of the AVT. Associated lesions of the AV and MV are treated on an individualized basis. Our case received AV and MV replacements. AV replacement was chosen instead of AV repair as the AV calcification was with a small aneurysm. MV replacement was selected instead of MV repair because (1) a significantly enlarged LV can increase the failure risk of MV repair, and (2) the patient was elderly. If the MV repair failed, he might not have endured the re-operation.
In conclusion, AVT is a rare congenital heart disease that commonly manifests as an abnormal communication between the ascending aorta and one of the ventricles. Herein, we presented a unique AVT case with abnormal communication among the ascending aorta, LV and RV. This special AVT has three orifices, i.e., one aortic opening, one LV opening, and one RV opening. This paper described the entire process from diagnosis to treatment of this unique case, thus providing some novel insights into AVT.
Availability of data and materials
Records and data pertaining to this case are in the patient's secure medical records in the Second Affiliated Hospital of Nanchang University.
Abbreviations
- AVT:
-
Aorto-ventricular tunnel
- ALVT:
-
Aorto-left ventricular tunnel
- ARVT:
-
Aorto-right ventricular tunnel
- AV:
-
Aortic valve
- MV:
-
Mitral valve
- LV:
-
Left ventricle
- RV:
-
Right ventricle
- LA:
-
Left atrium
- RA:
-
Right atrium
- ECG:
-
Electrocardiogram
- TTE:
-
Transthoracic echocardiography
- CDFI:
-
Color Doppler flow imaging
- CTA:
-
Computed tomography angiography
- CAG:
-
Coronary artery angiography
References
McKay R. Aorto-ventricular tunnel. Orphanet J Rare Dis. 2007;2:41. https://doi.org/10.1186/1750-1172-2-41.
Levy MJ, Lillehei CW, Anderson RC, et al. Aortico-left ventricular tunnel. Circulation. 1963;27:841–53. https://doi.org/10.1161/01.CIR.27.4.841.
Cook AC, Fagg NL, Ho SY, et al. Echocardiographic-anatomical correlations in aorto-left ventricular tunnel. Br Heart J. 1995;74(4):443–8. https://doi.org/10.1136/hrt.74.4.443.
Martins JD, Sherwood MC, Mayer JEJ, et al. Aortico-left ventricular tunnel: 35-year experience. J Am Coll Cardiol. 2004;44(2):446–50. https://doi.org/10.1016/j.jacc.2004.04.032.
Zyła-Frycz M, Lapa P, Baranowska A, et al. An aortico-left ventricular tunnel with aortic stenosis: Diagnosis based on echocardiography in a neonate. Cardiol J. 2007;14(2):193–7.
Corno AF, Durairaj S, Anderson RH. Aorto-Right Ventricular Tunnel in Transposition of the Great Arteries. Front Pediatr. 2018;6:30. https://doi.org/10.3389/fped.2018.00030.
Chen LL, Zhang CQ, Gong LG. A special type aortico-left ventricular tunnel with bicuspid aortic valve. Int J Cardiovasc Imaging. 2020;36(1):55–7. https://doi.org/10.1007/s10554-019-01692-9.
Xia H, Jiang Y, Xu Y, et al. Transesophageal Echocardiography for the Evaluation of Aorto-Left Ventricular Tunnel in Adults, with Follow-ups. Echocardiography. 2015;32(8):1270–6. https://doi.org/10.1111/echo.12870.
Minamimura H, Ishikawa T, Murakami T, et al. Aortic valve aneurysm associated with infective endocarditis: case report and review of literature. Gen Thorac Cardiovasc Surg. 2017;65(7):408–14. https://doi.org/10.1007/s11748-016-0681-9.
Djukic M, Djordjevic SA, Dähnert I. Transcatheter closure of a residual aorto-left ventricular tunnel: report of a case with a 6-year follow-up. Cardiol Young. 2017;27(8):1618–21. https://doi.org/10.1017/S1047951117000701.
Vijayalakshmi IB, Chitra N, Prabhu Deva AN. Use of an Amplatzer duct occluder for closing an aortico-left ventricular tunnel in a case of noncompaction of the left ventricle. Pediatr Cardiol. 2004;25(1):77–9. https://doi.org/10.1007/s00246-003-0548-6.
Chowdhury UK, Anderson RH, George N, et al. A Review of the Surgical Management of Aorto-ventricular Tunnels. World J Pediatr Congenit Heart Surg. 2021;12(1):103–15. https://doi.org/10.1177/2150135120954809.
Mueller C, Dave H, Prêtre R. Surgical repair of aorto-ventricular tunnel. Multimed Man Cardiothorac Surg. 2012;2012:mms006. https://doi.org/10.1093/mmcts/mms006.
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CY first diagnosed this case, prepared all TTE images, and drew the schematic diagram. JY’s team performed the surgery for the patient. XH further diagnosed this case by the CTA and prepared all CTA images. JW wrote and edited the manuscript. All authors read and approved the final manuscript.
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Additional file 5.
Additional file 7.
Additional file 8: Table S1.
The main parameters of the laboratory test.
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Yang, C., Yang, J., Huang, X. et al. Aorto-ventricular tunnel with three orifices: a unique case report diagnosed by transthoracic echocardiography. Cardiovasc Ultrasound 21, 5 (2023). https://doi.org/10.1186/s12947-023-00303-x
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DOI: https://doi.org/10.1186/s12947-023-00303-x