Correction to: Cancer Cell Int (2019) 19:1 https://doi.org/10.1186/s12935-018-0719-4
Following publication of the original article [1], the authors notified us that the graph presented in Figure 3a is the same as Figure 2a in the published manuscript. Figure 3 below represents the true migration values achieved for cells blocked in interphase and treated with the different compounds.
Migration of interphase arrested cells is inhibited by ESE-15-one and ESE-one exposure. a MDA-MB-231 cells were first blocked in G1/S by exposure to thymidine before cell free zones were generated and cells were exposed to 0.2% DMSO, 0.5 μM ESE-15-one or 0.5 μM ESE-one. Cell migration into the cell-free zone was quantified after 18 h. The graph represents the average of at least three repeats with error bars representing SEM. *P < 0.001 in t-test comparison with DMSO-treated cells. b Light microscopy images of cell migration assays showing interphase cells at time 0 h and after 18 h treated with DMSO, ESE-15-one or ESE-one. Scale bar is 400 μm
Specifically, blocked cells treated with DMSO closed 35% of the wound while ESE-15-one reduced that to 23% and ESE one reduced this to 13%. T tests show statistical significance.
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van Vuuren RJ, Botes M, Jurgens T, Joubert AM, van den Bout I. Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization. Cancer Cell Int. 2019;19:1. https://doi.org/10.1186/s12935-018-0719-4.
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van Vuuren, R.J., Botes, M., Jurgens, T. et al. Correction to: Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization. Cancer Cell Int 20, 308 (2020). https://doi.org/10.1186/s12935-020-01408-3
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DOI: https://doi.org/10.1186/s12935-020-01408-3