Abstract
Background
Lymphoepithelioma-like carcinoma of the lung is a rare primary malignancy of the lung, accounting for only 0.9% of primary malignancies of the lung. Those associated with cavities are even rarer, with fewer than five cases reported in the English literature. Concurrently, the imaging findings of tumors are usually non-specific, resulting in insufficient understanding of the disease by clinicians, thus leading to misdiagnosis and delayed treatment.
Case presentation
A 42-year-old female presented with a right lower lung mass with cavities. First identified on chest computed tomography (CT) in 2021, the mass persisted for 1 year and subsequently enlarged on chemotherapy and routine follow-up CT. Right lower lobectomy was then performed. Postoperative pathology confirmed primary pulmonary lymphoepithelioma-like carcinoma. After 10 months of follow-up, the patient was still alive and no recurrence was observed.
Conclusions
This article aims to describe a rare case of cavitary lymphoepithelioma-like carcinoma of the lung and review it clinical and imaging characteristics reported in previous cases, which will be helpful for clinicians and imaging physicians in diagnosing this disease.
Similar content being viewed by others
Explore related subjects
Find the latest articles, discoveries, and news in related topics.Background
Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma that often occurs in the nasopharynx and foregut derived organs, such as the stomach, thymus, and liver [1]. In the literature, 56.22% of LELCs occurred in the nasopharynx, followed by 21.32% in the non-nasopharyngeal head and neck, and 7.83% in the respiratory system [2]. The incidence of primary pulmonary LELC is rare, making up only 0.9% of all primary lung cancers [3]. Women and non-smokers are generally affected by pulmonary LELC, which has a strong association with Epstein-Barr virus [4]. LELC is nonspecific, usually resembling bronchial carcinoma, and present as a solid soft tissue mass in the lung [5]. In rare cases the tumor unexpectedly shows a cavity. It is difficult to distinguish pulmonary LELC from other lung cancers on imaging. Here, we report a rare case of cavitary lymphoepithelioma-like carcinoma of the lung, which has few been reported before, and review the previous clinical and imaging characteristics associated with pulmonary LELC to provide radiologists with a broader idea in the diagnosis and differential diagnosis of pulmonary tumors.
Case presentation
A 42-year-old woman presented to our hospital with cough and expectoration for more than one year. There were no symptoms of fever, chest pain, nausea and vomiting. Upon physical examination, the bilateral thorax was symmetrical, and the respiratory sounds of both lungs were clear. The sound was clear after percussion, and no dry-wet rales were heard. There was no abnormality in the laboratory examination. The chest CT scan showed an irregular mass (59 mm×31 mm) in the right lower lobe, with irregular cavities, uneven inner cavity walls, and mural nodules (Fig. 1). Because it was difficult to diagnose only by imaging and laboratory examination, the patient underwent lung biopsy. The pathology after biopsy of the right lung showed poorly differentiated carcinoma, combined with immunohistochemistry in line with LELC. According to the nature of the tumor, the patient received 6 rounds of chemotherapy with paclitaxel, sintigerism and carboplatin injection for 5 months. During the follow-up period, chest CT showed that the solid part of the tumor was growing (Figs. 2 and 3). Positron emission tomography-computer tomography (PET-CT) showed a space-occupying lesion with increased metabolism in the lower lobe of the right lung, and a malignant neoplastic lesion was considered (Fig. 4). A video-assisted thoracoscopic right lower lobe tumor resection was performed. Postoperative histopathology showed a large number of tumor cells and plasma cells as seen by hematoxylin and eosin (HE) staining. The tumor cells had scanty cytoplasm, irregular nuclei, large nucleoli, and were dark in color. Mitoses were active and plasma cells were abundant (Fig. 5A and B). Molecular pathology revealed the tumor to be EBER/ISH (+) (Fig. 5C). On the eighth postoperative day, the patient recovered and was discharged without surgery-related complications. After the operation, the patient was followed up via telephone for 10 months. There was no particular discomfort or related complications.
18 F-FDG PET/CT images. Right lung lesion showed an irregular mass, central cavity and annular marked FDG uptake with maximum standardized uptake value (SUVmax) of 20.7 (black arrow); (A) Axial lung window; (B) Axial soft tissue window ; (C) PET/CT fusion image;(D) PET ; (E) Maximum intensity projection image of whole body
Discussion and conclusions
A literature review was performed using relevant articles in English from the PubMed and Web of Science databases. The period of research was set from January 1, 1984 to October 18, 2022, using the following keywords: “lung”, “lungs”, “pulmonary”, “lymphoepithelioma-like carcinoma”, and “lymphoepitheliomatous carcinoma”. These words were used individually “OR” with the Boolean operator “AND”. A total of 82 articles were analyzed from 1984 to 2022. The flow chart of the literature screening process is described in Fig. 6. Finally, three 3 articles involving three cases were included for analysis. For each case, the first author’s name, year of publication, and patient’s age, sex, size, symptoms, tumor location, imaging characteristics, and follow up results were recorded (Table 1). Our results showed that pulmonary LELC had previously appeared in patients between 35 and 76 years of age, and most of these patients presented with nonspecific symptoms such as cough and sputum production. However, only four of them had combined cavities (including ours). Of the four patients, one was male and three were females, The lesions were located in the right lung in three patients, all four patients underwent surgery, and three patients were discharged from the hospital.
We report a 42-year-old female patient who presented with a right lower lung mass with cavities on CT, having thick and irregular cavity walls and small mural nodules. Combined with the clinical presentation and chest CT findings, a malignant lung tumor was highly suspected by clinicians. Some studies have reported [6] that pulmonary cavitary lesions are commonly found in pulmonary tuberculosis and lung squamous cell carcinoma. Tuberculosis or aspergillosis cavities often have smooth thin walls, while squamous cell carcinoma of the lung usually has other malignant characteristics including irregular margins and cavities with thick wall. In our case, the lesion presented as a lung mass with irregular thick-walled cavities and mural nodules, strongly suggesting squamous cell carcinoma. However, surprisingly, the final pathological findings revealed the tumor to be LELC rather than squamous cell carcinoma of the lung.
LELC is a rare lung cancer that accounts for only 0.9% of all primary lung cancers [7]. The World Health Organization (WHO) classifies it as a subtype of large cell carcinoma [8]. Bégin et al. first reported the disease in 1987 [4]. Smoking does not seem to have a significant impact on primary pulmonary LELC, unlike non-small cell lung cancer [9]. Primary pulmonary LELC has few specific clinical manifestations at the time of diagnosis, and larger tumors may presents with a variety of clinical signs and symptoms, such as cough, sputum production, hemoptysis, chest pain, and weight loss [10].
CT remains an important examination method for the diagnosis and differential diagnosis of pulmonary LELC [11]. These tumors are mainly located in the lower lobes of both lungs, close to the mediastinum and the pleura, and present as a round, round-like or lobulated solid mass. In the later stage of the disease, the bronchi and large vessels may be invaded, forming a vascular embedding sign, which is rarely accompanied by a cavity [7]. They mainly show high 18 F-FDG uptake on PET-CT [9]. Because this disease was combined with cavities, it was difficult to differentiate from common cavitary lesions in the lung, such as peripheral lung cancer, pulmonary tuberculosis and lung abscess. Cavities are found relatively frequently in primary lung cancer, with an incidence of up to 22% on CT [12], with squamous cell carcinoma being the main culprit. Squamous cell carcinoma usually shows eccentric thick-walled cavities with uneven walls, visible burrs, and a pleural indentation sign [13]. Therefore, pulmonary LELC is difficult to distinguish from pulmonary squamous cell carcinoma. Tuberculosis-associated cavities account for about 40% of cases, with most being central cavities with even wall thickness. Sometimes liquid level is observed in the cavity along, with satellite foci [14]. The cavity wall of a lung abscess is generally smooth, and a gas-liquid level or liquid-liquid level can be seen inside [12, 15].
At present, pathological examination is the only method for the diagnosis of LELC [16]. Immunohistochemistry commonly shows positivity for CK, EMA, CK5/6, P40, and p63 in LELC [17]. Treatment is determined based on the cancer stage and comorbidities. Treatment modalities include surgery, chemotherapy, radiotherapy and even targeted therapy. The most effective treatment for early pulmonary LELC is complete resection of the tumor with very good results. In the advanced stage, combination therapy is the best option [18]. Lymphoepithelioid cancer has a better prognosis than other types of lung cancer [19].
Pulmonary LELC has been reported in most cases in the form of solid soft tissue masses in the lung. In rare cases, tumors unexpectedly exhibit cavitary lesions; to our knowledge there are only four cases (including our case), thus easily misleading physicians to diagnose other tumors of the lung or other diseases. Our case demonstrates that LELC can have manifestations other than solid soft tissue masses, but also demonstrates that thick-walled cavities are not limited to common malignant tumors of the lung such as squamous cell carcinoma of the lung.
In conclusion, we report a case of pulmonary LELC in a patient who presented with rare cavitation on chest CT. Although very rare, LELC should be considered in the diagnosis and differential diagnosis of pulmonary cavitary lesions of unknown origin.
Data Availability
All data generated or analysed during this study are included in this published article.
Abbreviations
- CT:
-
Computed tomography
- LELC:
-
Lymphoepithelioma-like carcinoma
- PET-CT:
-
Positron emission tomography-computed tomography
- HE:
-
Hematoxylin and eosin
References
Ma H, Wu Y, Lin Y, Cai Q, Ma G, Liang Y. Computed tomography characteristics of primary pulmonary lymphoepithelioma-like carcinoma in 41 patients. Eur J Radiol. 2013;82(8):1343–6. https://doi.org/10.1016/j.ejrad.2013.02.006.
Qi WX, Zhao S, Chen J. Epidemiology and prognosis of lymphoepithelioma-like carcinoma: a comprehensive analysis of surveillance, epidemiology, and end results (SEER) database. Int J Clin Oncol. 2021;26(7):1203–11. https://doi.org/10.1007/s10147-021-01921-z.
Xuan H, Zhengjun C, Yang H, Guohan C. Case report: mutation analysis of primary pulmonary lymphoepithelioma-like carcinoma via whole-exome sequencing. Diagn Pathol. 2019;14(1):67. https://doi.org/10.1186/s13000-019-0811-7.
Bégin LR, Eskandari J, Joncas J, Panasci L. Epstein-barr virus related lymphoepithelioma-like carcinoma of lung. J Surg Oncol. 1987;36(4):280–3. https://doi.org/10.1002/jso.2930360413.
Patel ND, Levy AD, Mehrotra AK, Sobin LH. Brunner’s gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. AJR Am J Roentgenol. 2006;187(3):715–22. https://doi.org/10.2214/AJR.05.0564.
Canan A, Batra K, Saboo SS, Landay M, Kandathil A. Radiological approach to cavitary lung lesions. Postgrad Med J. Published online September 15, 2020:postgradmedj-2020-138694. doi:https://doi.org/10.1136/postgradmedj-2020-138694.
Mo Y, Shen J, Zhang Y, et al. Primary lymphoepithelioma-like carcinoma of the lung: distinct computed tomography features and associated clinical outcomes. J Thorac Imaging. 2014;29(4):246–51. https://doi.org/10.1097/RTI.0000000000000070.
Weissferdt A. Large cell carcinoma of lung: on the verge of extinction? Semin Diagn Pathol. 2014;31(4):278–88. https://doi.org/10.1053/j.semdp.2014.06.005.
Lei Y, Zhou J, Liu J, et al. The CT and PET/CT findings in primary pulmonary lymphoepithelioma-like carcinoma with pathological correlation: a study of 215 cases. Clin Radiol. 2022;77(3):e201–7. https://doi.org/10.1016/j.crad.2021.10.010.
Ho JC, Wong MP, Lam WK. Lymphoepithelioma-like carcinoma of the lung. Respirology. 2006;11(5):539–45. https://doi.org/10.1111/j.1440-1843.2006.00910.x.
Ooi GC, Ho JCM, Khong PL, Wong MP, Lam WK, Tsang KWT. Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma. Eur Radiol. 2003;13(3):522–6. https://doi.org/10.1007/s00330-002-1535-7.
Gafoor K, Patel S, Girvin F, et al. Cavitary Lung Diseases. Chest. 2018;153(6):1443–65. https://doi.org/10.1016/j.chest.2018.02.026.
Chiu FTS. Cavitation in Lung cancers. Aust N Z J Med. 1975;5(6):523–30. https://doi.org/10.1111/j.1445-5994.1975.tb03856.x.
Gafoor K, Patel S, Girvin F, et al. Cavitary Lung Diseases: a clinical-radiologic Algorithmic Approach. Chest. 2018;153(6):1443–65. https://doi.org/10.1016/j.chest.2018.02.026.
Gadkowski LB, Stout JE. Cavitary Pulmonary Disease. Clin Microbiol Rev. 2008;21(2):305–33. https://doi.org/10.1128/CMR.00060-07.
Jiang WY, Wang R, Pan XF, et al. Clinicopathological features and prognosis of primary pulmonary lymphoepithelioma-like carcinoma. J Thorac Dis. 2016;8(9):2610–6. https://doi.org/10.21037/jtd.2016.08.40.
Lin L, Lin T, Zeng B. Primary lymphoepithelioma-like carcinoma of the lung: an unusual cancer and clinical outcomes of 14 patients. Oncol Lett. 2017;14(3):3110–6. https://doi.org/10.3892/ol.2017.6510.
Zeng Z, Ding W, Luo F, Lin F. Lung cavity accompanied by hemoptysis: lymphoepithelioma-like carcinoma. QJM. 2018;111(9):643–4. https://doi.org/10.1093/qjmed/hcy091.
Chen J, Gu C, Chen X, et al. Clinicopathological and prognostic analyses of 86 resected pulmonary lymphoepithelioma-like carcinomas. J Surg Oncol. 2021;123(2):544–52. https://doi.org/10.1002/jso.26276.
Acknowledgements
Not Applicable.
Funding
None.
Author information
Authors and Affiliations
Contributions
GC and QY: manuscript writing. HR: manuscript revision. XL: collection of data or analysis. TZ: conception and critical review. All authors contributed to the article and approved the submitted version.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
This study was approved by the ethics committee of The Affiliated Hospital of Zunyi Medical University.
Informed consent
was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Competing interests
All authors listed above have no conflicts of interest to declare.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Chen, G., Yu, Q., Ran, H. et al. Rare cavitary lymphoepithelioma-like carcinoma of lung: clinical experience and literature review. BMC Pulm Med 23, 246 (2023). https://doi.org/10.1186/s12890-023-02529-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s12890-023-02529-x