Antibiotic resistance is one of the greatest threats to global public health. Inappropriate use of antibiotics can lead to an increase in antibiotic resistance. Individual self-efficacy in the appropriate use of antibiotics plays a key role, especially in China where the population has easy access to antibiotics. However, there are no tools available to assess the self-efficacy of appropriate antibiotic use for Chinese adults. We aimed to translate and develop a Chinese version of the Appropriate Antibiotic Use Self-Efficacy Scale (AAUSES), and validate its reliability and validity.
A total of 659 adults were recruited to participate in the questionnaire. The original version scale was first translated into Chinese using the backward and forward translation procedures. The internal consistency reliability of the scale was measured by the Cronbach alpha coefficient, the test-retest reliability, and the corrected item-total correlation. The validity of the scale was assessed by the content validity index, exploratory factor analysis, and confirmatory factor analysis.
The content validity index of the scale was 0.96. Exploratory factor analysis (EFA) supported a 4-factor structure of the translated questionnaire, and the discriminant validity of the scale was good. Confirmatory factor analysis (CFA) showed in the model fitness index, the chi-square degree of freedom was 2.940, the goodness-of-fit index(GFI) was 0.929, the incremental fit index (IFI) was 0.908, the comparative fit index(CFI) was 0.906, root mean square error of approximation(RMSEA) was 0.077, and standardized root mean residual (SRMR) was 0.0689, and the model fitting indexes were all in the acceptable range. Cronbach alpha coefficient for the scale was 0.910. The test-retest reliability was 0.947, and the corrected item-total correlations for the items ranged from 0.488 to 0.736. Self-efficacy for appropriate antibiotic use in adults varied by education, occupation, income, place of residence, and whether or not they had heard of antibiotic resistance.
The results indicated that the Chinese version of the AAUSES had good reliability and validity. Therefore, it can be considered a tool to evaluate the appropriate antibiotic use self-efficacy of adults in China.
Antibiotics are among the most cost-effective and life-saving drugs, helping to extend the life expectancy of patients . Researchers predicted that without dramatic changes, antibiotic consumption in 2030 could be 200% higher than in 2015 . However, inappropriate and excessive use of antibiotics is a significant contributor to antibiotic resistance . Antibiotic resistance has led to serious public health and economic consequences, with drug-resistant infections causing approximately 700,000 deaths globally each year. This number is expected to increase to 10 million by 2050, with associated costs of up to USD100 trillion globally if no action is taken . Therefore, it is important to take action to combat antibiotic resistance.
The widespread inappropriate use of antibiotics by humans has accelerated the development of antibiotic resistance [5,6,7]. Globally, more than 50% of pharmacy customers buy antibiotics without a prescription, and this situation is even worse in developing countries [8, 9]. A review showed that the prevalence of antibiotic self-medication in South East Asia is around 50% , and approximately 43% of patients worldwide use antibiotics to treat respiratory infections . Although antibiotics are prescribed, available research suggests that people’s behavior also plays a role in the irrational use of antibiotics [12,13,14], such as buying antibiotics over-the-counter, self-medicating with antibiotics, and storing and sharing antibiotics [15, 16] In addition, public behavior can also influence the rational use of antibiotics by doctors through expectations and pressure to use antibiotics, which is also seen as a key factor leading to unnecessary use of antibiotics by doctors [17, 18].
China is one of the countries that consume the most antibiotics and has one of the highest prevalence of antimicrobial resistance in the world [19, 20]. Excessive and irrational use of antibiotics has also been a concern in China. For example, more than half of all customers in China can obtain antibiotics without a prescription , which may further exacerbate antibiotic self-medication. And a considerable proportion of people cannot appropriately use antibiotics. The Chinese State Food and Drug Administration surveyed 7915 residents, 23.9% of whom said that when they had a cold, they would take antibiotics themselves rather than see a doctor . Another study conducted in rural areas of China found that 46.3% of villagers experienced antibiotic self-medication . It is estimated that about 58% of antibiotic misuse is due to irrational use of antibiotics by the general population, while doctors prescribe irrational antibiotics in 42% .
Existing studies have found that inappropriate antibiotic is associated with the following reseasons: antibiotic prescribing by non-infectious disease physicians , antibiotic dispensing in pharmacies [26, 27], and public knowledge, attitude and practice of antibiotic use . The factors determining the appropriate use of antibiotics by individuals are influenced by several aspects, including consumers’ lack of knowledge about the appropriate use of antibiotics and their adverse effects [29,30,31], as well as their beliefs, expectations and personal experiences with antibiotics [32, 33]. Knowledge, attitudes and practice (KAP) studies are often a preferred method to achieve this [34,35,36,37]. These KAP studies focused on knowledge, attitudes and misconceptions about antibiotics and irrational behavior, but did not delve into the self-efficacy of individuals to use antibiotics rationally and were limited methodologically to disaggregated survey data.
Self-efficacy is one of the most powerful predictors of behavior change and disease self-management [38,39,40]. The concept of self-efficacy was first introduced by Bandura, an American psychologist, and is a core concept in Bandura’s social cognitive theory, self-efficacy is defined as the belief that one can successfully perform a behavior to achieve the desired outcome [41, 42]. Because self-efficacy beliefs work in conjunction with goals, outcome expectations, perceived environmental barriers and facilitators that regulate human motivation, behavior and well-being, the concept of self-efficacy has been used in pharmacotherapy practice [43,44,45], several medication self-efficacy scales also have been developed [46,47,48,49].
However, there is a lack of tools to measure the self-efficacy of rational antibiotic use. To assess this individual self-efficacy in the rational use of antibiotics, Erin M, Hill et al. first developed the Appropriate Antibiotic Use Self-Efficacy Scale (AAUSES). The AAUSES is a concise and validated instrument for measuring self-efficacy in the appropriate use of antibiotics . At present, the scale is not used in other countries. Further confirmation is needed as to whether the AAUSES can be used directly to assess self-efficacy for rational antibiotic use in Chinese adults.
The study aimed to translate the original AAUSES translated into Chinese and further examine its reliability and validity among Chinese adults. Furthermore, we hypothesized that self-efficacy for rational antibiotic use was related to sociodemographic characteristics and clinical variables. Therefore, we compared the differences in the Chinese version of the AAUSES scores between different general data to validate our view.
Study design and participants
This study was a cross-sectional study and was conducted with a convenient sample of adults(age ≥ 18 years) from March to May 2021. Data was collected using Questionnaire Star, an online data collection platform in China. Two weeks later, 30 adults who participated in the first test were recruited to evaluate the test–retest reliability. The researchers examined the data and excluded questionnaires that had obvious logical errors and did not meet the criteria for this study (e.g., those < 18 years old). In this study, a total of 659 individuals took part in the survey. The survey was anonymous, but 30 of the participants who took part in the test were asked to write down their contact details so that the test–retest reliability could be assessed after two weeks. According to the guidelines for sample size, 5–10 participants per scale item would be sufficient to adequately test the validity and reliability of the scale . The AAUSES has 13 items and the required sample size was calculated to be at least 65–130 participants. In this study, a total of 659 individuals took part in the survey. All participants are native Mandarin speakers and provided informed consent before participating in the study. The research procedures complied with the ethical standards of the Ethics Committee of Jinzhou Medical University (Grant Number:JZMULL2021009) as well as adhered to the ethical principles of the Helsinki declaration .
Before translation and validation, we obtained professor Hill EM’s permission. The forward–backward translation method according to the Brislin translation was used . Firstly, The AAUSES has been independently translated into Chinese by one medical specialist and a psychologist. Secondly, the two experts and the researchers compared the translated Chinese versions of the questionnaire, discussed and corrected inconsistencies, and obtained a first draft of the Chinese version. Then, we invited two specialist in English who had not been exposed to the AAUSES to translate the first draft of the Chinese into English. Finally, the expert group compared and discussed the original scale, the first draft of the Chinese translation and the back-translated English scale. Changes were made to controversial items, focusing on linguistic and cultural adjustments to make the scale more appropriate for the Chinese context. A preliminary study was conducted with 10 adults. They were invited to complete the scale and were then asked about their understanding of the scale entries. They reported no difficulties in understanding and eventually developed the final Chinese version of the scale.
All participants completed the Chineses version of Appropriate Antibiotic Use Self-Efficacy Scale (AAUSES)  and the general self-efficacy scale (GSES) . In addition, participants were asked to complete general profile information, including socio-demographic and clinical variables related to antibiotics. General data information included gender, age, education, place of residence, marital status and religion, occupation, availability of health insurance and monthly household income, and clinical variables include whether you have taken antibiotic, whether you have taken antibiotics to treat a cold or flu, the number of times you have used antibiotic to treat a cold or flu, whether you have heard of antibiotic resistance, the level of concern about resistance to antibiotic.
The Appropriate Antibiotic Use Self-Efficacy Scale (AAUSES)
The Appropriate Antibiotic Use Self-Efficacy Scale (AAUSES) was originally developed by Erin Hill et al., and is used to assess self-efficacy for appropriate antibiotic use in adults . The scale consists of 13 items grouped into three subscales (minimization of antibiotics and trust in physician recommendations, avoidance of antibiotics for viral infections, and avoidance of taking old/ others’ antibiotics). The scale is evaluated on an 11-point scale. The total scores range from 0 (No confidence at all) to 100 (Totally confident), and higher scores indicate greater self-efficacy for appropriate antibiotic use. The original English version of AAUSES has shown good reliability and validity .
The General Self-Efficacy Scale (GSES)
The General self-efficacy scale (GSES) developed by Jerusalem and Schwarzer . This scale measures an individual’s confidence in his or her ability to cope with a wide range of stressful or challenging demands. The GSES has been translated into Chinese, and the Chinese version of the GSES (C-GSES) has demonstrated good reliability with Cronbach’s alpha of 0.91 . The scale consists of 10 items, and was scored on a 4-point Likert scale, with 1 indicating not at all correct and 4 indicating completely correct, with a unidimensional factor structure . The sum of all items is the general self-efficacy score and the total score ranges from 10 to 40, with higher scores indicating higher self-efficacy.
Data analysis was performed using SPSS version 26.0 (IBM SPSS Statistics 26.0, Armonk, NY, USA) and AMOS version 26.0 (SPSS, Chicago, IL, USA). Continuous data were expressed as mean (SD) and categorical data as percentages. Independent samples t-tests or one-way ANOVAs were used to analyze differences in Chineses version of AAUSES scores between sociodemographic categorical and clinical variables, and Bonferroni tests were used to calibrate the test levels for pairwise comparisons. A significance level of P < 0.05 was used. The skewness and kurtosis were calculated for each item to determine if the data were normally distributed. When the skewness and kurtosis were between-2 and +2, the data were considered to be normally distributed .
Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA)
EFA and CFA were used to examine the construct validity of the Chinese version of AAUSES. The sample of 659 cases was randomly divided into two groups, one group consisted of 331 individuals for EFA, and 328 individuals for CFA.
In the sample 1 (n = 331), a principal component analysis (PCA) with Varimax rotation was used to assess the internal structure of the translated the Chinese version of AAUSES. The sample adequacy for the factorability was assessed by the Kaiser-Meyer-Olkin (KMO)  metric and Bartlett test of sphericity , and sampling was considered adequate when the KMO value was greater than 0.6 and the Bartlett test of sphericity was significant (P < 0.05). The factors with eigenvalues > 1 were selected, and the maximum variance orthogonal rotation of the factors was performed. Items with loading values greater than or equal to 0.40 were considered for inclusion in a separate factor . Factors were extracted on the basis of eigenvalues, explained total variance and Scree plot.
In the sample 2 (n = 328), CFA was conducted in order to verify the EFA result or test measurement model. CFA can facilitate further evaluation regarding the fitness of the model in line with the structure of the factors . To evaluate the goodness-of-fit of the models, the following indices were evaluated: Chi-square(χ2) and degrees of freedom(df), root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR), normed fit index (NFI), goodness of fit index (GFI) and comparative Fit Index (CFI) . A model with χ2/df < 3, RMSEA and SRMR < 0.08 , and a GFI, CFI and an IFI > 0.90  is considered acceptable.
Content validity index (CVI) was used to evaluate the content validity of the Chinese version of AAUSES. The CVI includes item-level content validity index (I-CVI) and average S-CVI (S-CVI/Ave) . Each expert scored the relevance of each item to the corresponding dimension. A 4-point scale (1 = no relevance, 2 = low relevance, 3 = strong relevance, 4 = very strong relevance) was used to calculate the CVI.
Discriminant validity and criterion validity
The total the Chinese version of AAUSES scores were sorted from lowest to highest, with the highest 27% of the sample grouped into one group and the lowest 27% into another, and the difference in item scores between the high and low groups was analysed using a two-tailed independent samples t-test. Discriminant validity was considered good if the scores for each item in both groups reached a significant level (p < 0.05). We analyzed criterion-related validity by comparing the Chinese version of AAUSES with the GSES scale using Spearman’s correlation.
Internal consistency reliability
The internal consistency reliability of the scale was determined by Cronbach alpha coefficient, corrected item- total correlation and retest reliability. Cronbach alpha coefficient equal to or greater than 0.70 is considered acceptable . The corrected item-total correlation, which indicates the correlation of each item with the sum of the other items in the scale, was used at a criterion of 0.3 . Retest reliability reflects the stability of the scale by calculating the retest correlation coefficient (intraclass correlation coefficient, ICC).
Two weeks after completing the first response, 30 adults who participated in the first test were recruited to evaluate the test-retest reliability. The correlation between the two tests was assessed using Spearman’s correlation. A correlation coefficient of 0.7 will be used as the recommended threshold .
Demographics and sample characteristics
In this study, there was a descending order of distribution of the respondents from younger to older age, with the highest percentage among the 18—30 years group (80.48%) and the lowest among those greater than 50 years old who accounted for only 3% of the sample. The majority of the participants were students (58.9%) and the sample was distributed almost equally between place of residence (42.0% live in the city while 58.0% live in the rural), the monthly income with the greatest prevalence among the respondents was less than Ұ10,000 (82.2%). The majority of respondents are females (67.7%), approximately 11.4% of the total number of people with a high school or junior college degree or less, almost 83% have health insurance. Demographic and background information about the sample is summarized in Table 1. The means and standard deviations for all 13 items tested are presented in Table 2, these data were normally distributed according to the skewness and kurtosis figures.
The content validity of the Chinese version of AAUSES was evaluated by expert evaluation. The expert group is composed of 6 experts including three psychology experts and three medical experts. The content validity analysis result shows that the I-CVI of the Chinese version of AAUSES is 0.833-1.000, and the S-CVI / Ave is 0.96, which has good content validity.
Exploratory factor analysis (EFA)
Before commencing an EFA, the factorability of the matrix of a sample (n = 331) was first examined. The Bartlett test  of sphericity was significant (χ278=1050.377; P < 0.001), and the KMO index was 0.777, which is greater than the minimum acceptable value of 0.6 , suggesting there is sufficient correlation between the variables and the matrix is appropriate for factor extraction. The result showed that four factors had an eigenvalue higher than 1 and yielded 4 common factors with a cumulative variance contribution of 60. 636%, these 4 extracted factors explained 25.08%, 13.32%, 11.21%, 11.02% of the variance, this differs from the 3-factor structural model of the original scale. The factor loadings of the 13 items ranged from 0.520 to 0.862, and all the items were loaded on a single factor, no items were deleted, the results are shown in Table 3. The 4-factor structure was further confirmed by the scree plot, as the descending tendency became weak after the fourth point. The scree plot is shown in Fig. 1.
Confirmatory factor analysis (CFA)
A CFA was performed on the sample 2 (n = 328). In the model fitness index, the chi-square degree of freedom was 2.940, the goodness-of-fit index (GFI) was 0.929, the incremental fit index (IFI) was 0.908, the comparative fit index (CFI) was 0.906, root mean square error of approximation(RMSEA) was 0.077, and standardized root mean residual (SRMR)was 0.0689. The CFA results are shown in Fig. 2.
Discriminant validity and correlations among factors
The Chinese version of AAUSES scores of the 659 survey respondents were ranked in order of high and low, and those with scores in the top 27% were grouped into one group and those with scores in the bottom 27% were grouped into another group. After calculation, 650 and 970 scores were selected as thresholds in this study, and those with AAUSES scores below 650 were categorized as the low group and those with scores above 970 were categorized as the high group, and the mean of each item score in the two groups was calculated. Two-tailed independent samples t-test showed there was a significant difference between the items in the two groups (p＜0.05). The specific statistical results are shown in Table 4.
Correlations among factors
The correlation analysis results (Table 5) showed that the Chinese version of AAUSES had a positive correlation between the total score and each dimension, and each dimension score and total score are positively correlated with the GSES score.
Internal consistency reliability
Reliability analysis results showed that the Chinese version of AAUSES had ideal internal consistency, with the overall Cronbach alpha coefficient being 0.910 and Cronbach alpha coefficients for the 4 factors being 0.911, 0.707, 0.742, and 0.939, all were greater than the minimum acceptable value of Cronbach alpha coefficient . Table 6 showed the correlation coefficient between the 13 items of the questionnaire and the total score, and presented the Cronbach alpha coefficients after removing an item from the questionnaire, all of which were lower than the Cronbach alpha coefficient of 0.90 before the removal. In addition, the corrected item-total correlations for the items ranged from 0.488 to 0.736, all of which were well above 0.3 . Therefore, all 13 items were retained and none were deleted.
Two weeks later, a random sample of 30 adults who participated in the first survey completed the questionnaire again and the Spearman correlation coefficient was 0.947, which was greater than 0.7, and the Chinese version of the AAUSES scale had good test-retest reliability.
Analysis of differences in chinese version of AAUSES with different sociodemographic information
Among the general demographic variables, there are statistically significant differences in the scores of the Chinese version of AAUSES among different education levels, occupations, per capita monthly income, family location, and whether there is medical insurance. Among the clinical variables, there were no differences in the total scores for whether or not they had taken antibiotics and the number of times they had taken antibiotics when they had a cold. However, those who had taken antibiotics for a cold or flu scored significantly lower than those who had not, and those who were very concerned about antibiotic resistance scored higher than those who had never heard of antibiotic resistance and those who were less concerned about antibiotic resistance people. The specific results are shown in Table 7.
To our knowledge, this study was the first attempt to introduce the scale to measure the appropriate antibiotic use self-efficacy of adults. We translated the scale into Chinese after a rigorous cultural adaptation process and validated a measure with adequate internal consistency, test-retest reliability, content validity, construct validity, and discriminant validity, which is especially suitable to evaluate the appropriate antibiotic use self-efficacy of adults. Finally, a Chinese version of the scale with 13 items and a four-factor structure was developed.
The chinese version of AAUSES has good reliability
Reliability analysis reflects the stability of the structure of the scale being measured . The reliability of the AAUSES was assessed using the Cronbach alpha coefficient, item-total correlations, and test–retest. In this study, the Cronbach alpha coefficient of the Chinese version of the AAUSES in this study was 0.910, which demonstrated adequate stability of AAUSES measures of individual self-efficacy for rational antibiotic use. The item-total score correlation coefficients were all above 0.30, which confirmed the Chinese version of AAUSES had good internal consistency. In addition, the ICC for the scale was 0.947 in the test–retest study. The results indicated that the Chinese version of AAUSES had stable repeatability.
The chinese version of AAUSES has good validity
Validity refers to the extent to which the measured tool accurately corresponds to the real world . We assessed the content validity, discriminant validity and construct validity of the scale. If the S-CVI/Ave is above 0.90, it is considered to have good content validity. The content validity of the Chinese version of AAUSES is 0.96, which has good content validity . The discriminant validity results showed that the score of each item in the 2 groups reached the level of significance (P < 0.05), which was considered good. It is generally accepted that the ideal structural validity should be such that (1) the factors extracted through exploratory analysis explain more than 40.00% of the total variance, and (2) each item has a loading value higher than 0.4 on a single factor and lower loading values on the other factors . In this study, four factors were extracted through exploratory factor analysis, explaining 60.636% of the variance in the total data. The factor loadings of the 13 items ranged from 0.520 to 0.862. Moreover, the CFA also showed that the individual Chinese version of AAUSES projects fit well with this four-dimensional structural model, as the model fit indices all meet acceptable criteria. Overall, the Chinese version of the AAUSES showed optimal validity among Chinese adults.
There is a reasonable explanation for the addition of a new dimension
This study determined finally that the scale is a four-dimensional structure (minimization of antibiotics and trust in physician recommendations (including items 7,8,10,11,12,13), avoidance of taking antibiotics based on previous medication experience(including items 1,2,4), avoidance of antibiotics for viral infections(including items 6,9), taking old/other people’s antibiotics(including items 3,5)). This differed from the three dimensional structure of the original version(minimization of antibiotics and trust in physician recommendations(including items 7,8,10,11,12,13), avoidance of antibiotics for viral infections(including items1,2,4,6,9), taking old/other people’s antibiotics(including items 3,5)) . In this study, the dimension of the original scale avoidance of antibiotics for viral infections (including items 1, 2, 4, 6, 9) was split into two dimensions. Based on expert opinions, literature review, and the underlying characteristics of the items, we renamed it avoidance of taking antibiotics based on previous medication experience (including items1, 2, 4) and avoidance of antibiotics for viral infections(including items 6,9), which proved to be more suitable for Chinese people. There are relatively reasonable explanations for item1, item2 and item4 on a common dimension. Firstly, during the translation process, cross-cultural adaptations have been made to items that do not conform to Chinese expression habits, which affected the original structure of the scale to some extent. Secondly, the use of antibiotics differs between domestic and foreign countries, it may be attributable to the differences in socio-economic and sample population. Thirdly, Bandura identified four main sources of self-efficacy beliefs: active mastery experiences, alternative experiences, verbal persuasion, and physiological responses. Mastery experiences are considered to be the most influential source of self-efficacy [72,73,74]. Active mastery experiences are interpreted as successful outcomes increasing self-efficacy and failed experiences decreasing self-efficacy. However, there is a low self-efficacy for rational antibiotic use due to the misconception of “previous medication experience”. Most people lack an understanding of the natural course of self-limiting illnesses and therefore assume that antibiotics are effective in treating viral infections based on previous experience with medication . Thus most customers with symptoms of colds, flu, bronchitis and respiratory infections (cough, runny nose, sore throat) go to pharmacies for antibiotics, yet these symptoms are usually viral . A survey by Joran showed that participants who self-administered antibiotics mainly used them for sore throats and influenza, with 35. 2% based on their previous experience with antibiotics . Therefore, we named this dimension avoidance of taking antibiotics based on previous medication experience.
Comparison of the original AAUSES and the chinese version of the AAUSES self-efficacy score
In this study, the self-efficacy score was much lower than the self-efficacy score for antibiotic use on the original scale . This may be related to socioeconomic differences and different sample populations. According to Levy and Marshall , in developing countries, antibiotics may be at greater risk of resistance. Because they are cheap and readily available and often used unnecessarily. In China, the Chinese have less knowledge about the rational use of antibiotics and are unaware that irrational antibiotic use can lead to antibiotic resistance, and misconceptions about antibiotic use are evident in the general population . The results of a study showed that about half of the population did not know that antibiotics do not treat colds or that they are not effective against viral infections . Compared with countries such as the United States and the United Kingdom, most efforts in China have focused on stewardship initiatives and regulations, training, and support for clinicians, while education efforts to improve antibiotic knowledge and promote the rational use of antibiotics have lagged relatively behind .
Analysis of differences in self-efficacy of general information on the rational use of antibiotics
We found that individuals with higher levels of education have higher self-efficacy scores for the rational use of antibiotics, the more literate and educated participants clearly understood the dosage and side effects of antibiotics and are more confident in their rational use of antibiotics. The results of a study in Nepal also showed that better educated respondents had a better understanding of antibiotics and had more appropriate attitudes and practices . We also found there were statistically significant differences between different occupations, with medical professionals having the highest scores and farmers having the lowest self-efficacy scores, This is consistent with a study investigating the Knowledge, Attitudes and Practice (KAP), which found that healthcare practitioners significantly outperformed non-practitioner group practice scores . However, a study in eastern Turkey found that farmers were far less aware of antibiotic use, duration, storage, and resistance than expected . There were statistically significant differences by household location, with urban households scoring significantly higher than rural households. Urban areas have a faster development of economic level than rural areas, richer sources of information, and urban residents are more likely to acquire antibiotic-related knowledge. A study in India showed that the prevalence of self-medication in rural populations was higher than in urban areas and the knowledge level of urban residents is higher than that of rural residents . There were statistically significant differences in health insurance status. A study finds significant differences in residents’ attitudes towards antibiotic use and whether they have medical insurance . Those who had heard of antibiotic resistance and those who were worried about antibiotic resistance had higher self-efficacy scores than those who had not heard of antibiotic resistance. Researchers found that respondents familiar with antibiotic-related knowledge are more likely to have a positive attitude towards antibiotic use and vice versa . This study also found that self-efficacy scores for rational antibiotic use were related to income, with higher income being associated with higher self-self-efficacy scores, which may be related to the fact that participants with higher income levels were less likely to self-treat [88, 89]. A study by Allcock et al.  showed that people with lower incomes more often go to pharmacies to buy antibiotics because they are cheap and readily available over the counter. This suggests that it is essential and urgent to inform the general population about the rational use of antibiotics and its consequences in less economically developed areas, especially in rural areas and among less educated people. Future systematic and in-depth research should be conducted on the factors that influence the self-efficacy of rational antibiotic use to provide a scientific basis for antibiotic managers to improve the self-efficacy of rational antibiotic use in adults.
To the best of our knowledge, this is the first study to translate and validate AAUSES in China, and some limitations should be acknowledged. Firstly, the majority of the study participants recruited for this study using convenience sampling were young and highly educated, so this may overestimate the level of self-efficacy scores for rational antibiotic use among Chinese adults and should therefore be validated in a broader population in the future. Secondly, as with most cross-sectional studies, there are inherent drawbacks such as recall bias and difficulty in inferring causal conclusions. Thirdly, this paper is the first study to localize the AAUSES, and thus the reliability and validity of the scale need to be further tested through future studies.
The Chinese version of the AAUSES, consisting of 13 items, and supporting a four-factor structure, demonstrated good validity and reliability in this study and proved to be a valid tool for assessing self-efficacy for appropriate antibiotic use among Chinese adults. In addition, future research should examine the psychometric properties of the Chinese version of AAUSES in a broader sample of Chinese adults, particularly in areas where the irrational use of antibiotics is more prevalent. We believe that there is a need to use the Chinese version of the AAUSES to assess the self-efficacy of Chinese adults in the rational use of antibiotics in future studies. In addition, future research should pay more attention to the relevant factors affecting the self-efficacy of rational use of antibiotics, this will provide a basis for public health authorities to develop policy guidance and interventions to improve public self-efficacy in the rational use of antibiotics, promote changes in irrational behavior in antibiotic use, and reduce the health hazards and economic losses caused by antibiotic resistance.
Availability of data and materials
The datasets generated and/or analysed during the current study are not publicly available due Chinese people are relatively secretive about their lives and thoughts, although informed consent was obtained from study subjects prior to the survey and the findings were largely reported but are available from the corresponding author on reasonable request.“
The Appropriate Antibiotic Use Self-Efficacy Scale
The General Self-Efficacy Scale
Principal components analysis
Exploratory Factor Analysis
Confirmatory Factor Analysis
Comparative Fit Index
Root Mean Square Error of Approximation
Standardized Root Mean Square Residual
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We thank the participants who helped us with this study and the authors of the Appropriate Antibiotic Use Self-efficacy scale, and we would like to thank Dr. Erin M. and Dr. Watkins for providing us with the tools and encouragement.
This work was supported by the Natural Science Foundation of Liaoning Province (No. 201602297).
Ethics approval and consent to participate
All procedures were carried out in accordance with the 1964 Helsinki declaration, and the research proposal was approved by the Ethics Committee of Jinzhou Medical University (JZMULL2021009). All study participants received informed consent.
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The authors declare that they have no competing interests.
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Wang, L., Liang, C., Yu, H. et al. Reliability and validity evaluation of the appropriate antibiotic use self-efficacy scale for Chinese adults. BMC Public Health 22, 1344 (2022). https://doi.org/10.1186/s12889-022-13729-1
- Appropriate antibiotic use
- Antibiotic resistance
- Antibiotics use self-efficacy
- Medication self-efficacy