Endovascular thrombectomy and post-procedural headache
We investigated the prevalence of post-procedural headache in patients who have undergone thrombectomy for ischemic stroke, and correlated history of migraine with risk of peri-procedural complications. A total of 314 patients underwent thrombectomy at the Danish National Hospital from January 2012 to December 2014. Eligible subjects were phone-interviewed using a purpose-developed semi-structured questionnaire according to the International Classification of Headache Disorders 3, beta version criteria.
Among 96 eligible subjects, there was a significant decrease in migraine (p = 0.022) within the first 3 months after EVT compared to 1 year before treatment, which was further evident at interview time (on average 1.6 years after EVT, p = 0.013). A minority of patients experienced headaches for the first time within 3 months of their EVT (migraine 2, TTH 9), which persisted at interview time for subjects with migraine. Out of 12 subjects with peri-procedural complications, 2 had a history of migraine with aura.
Thrombectomy leads to a significant decrease in previously known migraine, and new onset of headache in a small subset of patients. A history of migraine does not appear to predispose to peri-procedural complications.
KeywordsEVT Stroke Risk Complications Migraine
Endovascular thrombectomy is an established procedure used to treat ischemic stroke. The risk of post-procedural headache has received little attention. Studies on the interplay between headache and endovascular treatment (EVT) are contradictory [1, 2, 3]. It is also unknown whether peri-procedural vascular complications are more prevalent in subjects with migraine history, or how such complications may affect headache patterns after EVT. To elucidate potential bidirectional links between endovascular thrombectomy, procedure-related complications, and headache we retrospectively assessed headache characteristics in a cohort of patients with ischemic stroke who had undergone thrombectomy.
We identified all patients who had undergone EVT for ischemic stroke at a tertiary referral center, Copenhagen, Denmark between January 2012 and December 2014. We assessed medical records of all identified cases (n = 314) and excluded those with: 1) procedures other than thrombectomy, and 2) aphasia, or no command of Danish or English.
Eligible patients were phone interviewed once, on average 1.6 years (range: 0.2–3.0) after EVT, using a purpose-developed semi-structured questionnaire. We collected information on headache status 1 year and 1 month before EVT and after EVT (3 months after and at time of interview).
All headaches were classified according to the International Classification of Headache Disorders 3, beta version .
Frequencies and percentages were calculated for categorical variables and medians and range for continuous variables. For comparisons of categorical data, we used the McNemar test. All p-values were two-sided and p-values below 0.05 were considered statistically significant. All analyses were performed using IBM® SPSS® Statistics version 23.
Clinical and demographic data in 96 stroke patients
Median age at EVT (years)
67 years (range: 28–90)
Median height (cm)
174 cm (range: 152–194)
Median weight (kg)
75 kg (range: 45–130)
Median pack yearsa
20 years (range: 1–92)
History of hypertension (n)
Medication history prior to EVT (n)
- Antithrombotic therapyb
- Antihypertensive therapyc
Medication status at interview time (n)
- Antithrombotic therapyb
- Antihypertensive therapyc
Thrombolysis treatment for stroke (n)
Procedures performed (n)
- Thrombectomy + stent
- Thrombectomy + coil + Onyx
Median time from procedure to interview (years)
1.6 years (range: 0.2–3.0)
Headache status before and after EVT
We also compared patients’ headache status 1 month before thrombectomy with 3 months after treatment. Here we found an increase in TTH (6 versus 16 subjects, p = 0.013), which persisted at interview time (6 versus 19 subjects, p = 0.002). For this time window, we saw no change in migraine.
De novo headaches after EVT
Two female subjects experienced de novo migraine-like headache (one with and one without aura, ages 45 and 90 years) within the first 3 months after EVT, both reporting persistent headache at interview time, 2.1 and 1.3 years after EVT, respectively.
Peri-procedural complications during EVT
In 12 of 96 subjects (12.5%), the thrombectomy procedure was complicated (Additional file 1: Figure S1 and Table S2). Peri-procedural complications arose in 8% of patients with a pre-EVT history of migraine (2 patients with migraine with aura) and 14% of patients with no history of migraine (n = 10).
Considering the focal intravascular manipulation inflicted on the vessels, headache after thrombectomy seems likely due to endothelial injury-induced inflammation of the intracranial vessel walls, activating sensory afferents. In support, a recent 3 T vessel wall MRI study reported contrast enhancement in arterial walls in patients treated with stent-retriever thrombectomy . The bidirectional link between headache and EVT has thus far never been investigated, hence it is unknown whether history of headache may influence the endovascular procedure due to vascular complications such as distal embolization or dissection (Additional file 1: Table S2), and vice versa whether a complicated procedure may affect headache patterns after EVT. Studies on familial hemiplegic migraine type-1 mutant mice show larger infarcts and worse neurological outcomes after stroke compared to wild-type mice , specifically suggesting that a diagnosis of migraine with aura may predispose to vascular complications during the thrombectomy procedure.
As a major finding, we report a significant drop in migraine prevalence after thrombectomy for subjects with pre-EVT history of migraine, resulting in prevalence estimates close to those for the general population. We lacked a control group to assess for decline in migraine prevalence over time irrespective of EVT. However, we believe that the reduction of migraine observed in our study is beyond what one would expect from the natural history of this disorder . This decrease could also be explained by the initiation of antithrombotic medication after thrombectomy . No new prophylactic migraine treatment was initiated after EVT.
Contrary to migraine, we found that thrombectomy led to an increase in TTH after EVT, with a significantly larger prevalence compared to 1 month prior to treatment. However, when comparing the post-procedural prevalence with 1-year prior to thrombectomy, we observed no change, suggesting that thrombectomy does not result in added headache burden in the larger scope of life-time headache evolution. Differences in post-procedural medication (such as antithrombotic treatment) cannot explain this disparity between migraine and TTH, as all subjects were started on antithrombotic treatment after thrombectomy.
We also report new onset of headache in a subset of subjects (11%) who undergo thrombectomy. This headache resolves over time for some TTH cases, but persists for those reporting de novo migraine, suggesting that a fraction (8%) of subjects treated with thrombectomy may develop persistent new headache. Any de novo headache that occurs with close temporal relation to EVT is per definition a secondary headache, however, the current ICHD-3 beta criteria only allow any such headache to last up to 24 h . This taxonomy is inadequate, as post-thrombectomy headache for the majority lasts at least 3 months, if not longer. Also, our results confirm the accepted notion that migraine with aura is overrepresented in a stroke cohort compared to the general population , and may even be larger in our cohort compared to other stroke case-based studies .
Finally, our results show that 12.5% of subjects undergoing thrombectomy experience peri-procedural complications. Albeit underpowered, these data suggest that migraine with aura does not increase the risk of complications during thrombectomy.
In conclusion, we have presented the first report of headache onset and prevalence after thrombectomy. Strengths of the study include a homogenous patient group, direct phone interviews, and ICHD-3 beta classification . Limitations include recall bias and a relatively small sample size. Nevertheless, we believe the data help improve our understanding of post-procedural headache to optimize counseling of subjects who undergo thrombectomy with resultant headache. Larger, statistically robust prospective studies are warranted to establish the direction and magnitude of changes in migraine and other headaches after thrombectomy and to further explore migraine as a risk factor for peri-procedural complications.
The authors would like to thank Henrik Steglich-Arnholm for his assistance with extracting medical records on peri-procedural complications for this study.
We thank the Lundbeck Foundation (R155-2014-171), the Novo Nordisk Foundation (NNF11OC1014333), and the European Union’s Seventh Framework programme (FP/-EUROHEADPAIN-no.602633).
SK designed and performed the study, with the help of FMA, DG, CA, and MA. SK, AMF, ZF, and JFP performed interviews. SK drafted the manuscript and performed the statistical analyses. KH and MH assisted with access to the patient data registry, medical record review, and valuable input to the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Ethics approval and consent to participate
The Committee on Health Research Ethics, Capital Region approved the study. All patients provided informed consent.
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