Braga ME, Leal PF, Carvalho JE, Meireles MA: Comparison of yield, composition, and antioxidant activity of turmeric (Curcuma longa L.) extracts obtained using various techniques. J Agric Food Chem. 2003, 51: 6604-6611. 10.1021/jf0345550.
CAS
Article
PubMed
Google Scholar
Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL: Curcumin content of turmeric and curry powders. Nutr Cancer. 2006, 55: 126-131. 10.1207/s15327914nc5502_2.
CAS
Article
PubMed
Google Scholar
Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK: Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. J Agric Food Chem. 2002, 50: 3668-3672. 10.1021/jf025506a.
CAS
Article
PubMed
Google Scholar
Hiserodt R, Hartman TG, Ho CT, Rosen RT: Characterization of powdered turmeric by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. J Chromatogr A. 1996, 740: 51-63. 10.1016/0021-9673(96)00103-3.
CAS
Article
Google Scholar
Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A, Tooyama I: Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease. Biomaterials. 2010, 31: 4179-4185. 10.1016/j.biomaterials.2010.01.142.
CAS
Article
PubMed
Google Scholar
Mutsuga M, Chambers JK, Uchida K, Tei M, Makibuchi T, Mizorogi T, Takashima A, Nakayama H: Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain. J Vet Med Sci. 2012, 74: 51-57. 10.1292/jvms.11-0307.
CAS
Article
PubMed
Google Scholar
Mohorko N, Repovs G, Popovic M, Kovacs GG, Bresjanac M: Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples. J Neuropathol Exp Neurol. 2010, 69: 405-414. 10.1097/NEN.0b013e3181d709eb.
CAS
Article
PubMed
Google Scholar
Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ: Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007, 102: 1095-1104. 10.1111/j.1471-4159.2007.04613.x.
CAS
Article
PubMed
Google Scholar
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM: Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005, 280: 5892-5901.
CAS
Article
PubMed
Google Scholar
Liu K, Guo TL, Chojnacki J, Lee HG, Wang X, Siedlak SL, Rao W, Zhu X, Zhang S: Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease. ACS Chem Neurosci. 2012, 3: 141-146. 10.1021/cn200122j.
PubMed Central
CAS
Article
PubMed
Google Scholar
Ono K, Hasegawa K, Naiki H, Yamada M: Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. J Neurosci Res. 2004, 75: 742-750. 10.1002/jnr.20025.
CAS
Article
PubMed
Google Scholar
Kim H, Park BS, Lee KG, Choi CY, Jang SS, Kim YH, Lee SE: Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid. J Agric Food Chem. 2005, 53: 8537-8541. 10.1021/jf051985c.
CAS
Article
PubMed
Google Scholar
Reinke AA, Gestwicki JE: Structure-activity relationships of amyloid β-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des. 2007, 70: 206-215. 10.1111/j.1747-0285.2007.00557.x.
CAS
Article
PubMed
Google Scholar
Chen SY, Chen Y, Li YP, Chen SH, Tan JH, Ou TM, Gu LQ, Huang ZS: Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease. Bioorg Med Chem. 2011, 19: 5596-5604. 10.1016/j.bmc.2011.07.033.
CAS
Article
PubMed
Google Scholar
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA: Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther. 2008, 326: 196-208. 10.1124/jpet.108.137455.
PubMed Central
CAS
Article
PubMed
Google Scholar
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001, 21: 8370-8377.
CAS
PubMed
Google Scholar
Wang YJ, Thomas P, Zhong JH, Bi FF, Kosaraju S, Pollard A, Fenech M, Zhou XF: Consumption of grape seed extract prevents amyloid-β deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox Res. 2009, 15: 3-14. 10.1007/s12640-009-9000-x.
Article
PubMed
Google Scholar
Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M: Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006, 10: 1-7.
PubMed
Google Scholar
Zhang C, Browne A, Child D, Tanzi RE: Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein. J Biol Chem. 2010, 285: 28472-28480. 10.1074/jbc.M110.133520.
PubMed Central
CAS
Article
PubMed
Google Scholar
Liu H, Li Z, Qiu D, Gu Q, Lei Q, Mao L: The inhibitory effects of different curcuminoids on β-amyloid protein, β-amyloid precursor protein and β-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells. Neurosci Lett. 2010, 485: 83-88. 10.1016/j.neulet.2010.08.035.
CAS
Article
PubMed
Google Scholar
Xiong Z, Hongmei Z, Lu S, Yu L: Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer's disease. Pharmacol Rep. 2011, 63: 1101-1108.
Article
PubMed
Google Scholar
Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM: β-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009, 29: 9078-9089. 10.1523/JNEUROSCI.1071-09.2009.
PubMed Central
CAS
Article
PubMed
Google Scholar
Park SY, Kim HS, Cho EK, Kwon BY, Phark S, Hwang KW, Sul D: Curcumin protected PC12 cells against β-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 2008, 46: 2881-2887. 10.1016/j.fct.2008.05.030.
CAS
Article
PubMed
Google Scholar
Wang J, Zhang YJ, Du S: The protective effect of curcumin on Aβ induced aberrant cell cycle reentry on primary cultured rat cortical neurons. Eur Rev Med Pharmacol Sci. 2012, 16: 445-454.
CAS
PubMed
Google Scholar
Ahmed T, Gilani AH: A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease. Brain Res. 2011, 1400: 1-18.
CAS
Article
PubMed
Google Scholar
Shen L, Ji HF: The pharmacology of curcumin: is it the degradation products?. Trends Mol Med. 2012, 18: 138-144. 10.1016/j.molmed.2012.01.004.
CAS
Article
PubMed
Google Scholar
Quitschke WW: Bioavailability and metabolism of curcuminoids. Natural Compounds as Inducers of Cell Death. Edited by: Diedrich M, Noworyta K. 2012, Heidelberg: Springer Verlag, 1: 95-125.
Chapter
Google Scholar
Hamaguchi T, Ono K, Yamada M: Curcumin and Alzheimer's disease. CNS Neurosci Ther. 2010, 16: 285-297. 10.1111/j.1755-5949.2010.00147.x.
CAS
Article
PubMed
Google Scholar
Quitschke WW: Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications. BMC Biotechnol. 2008, 8: 84-10.1186/1472-6750-8-84.
PubMed Central
Article
PubMed
Google Scholar
Campell SK, Switzer RC, Martin TL: Alzheimer's plaques and tangles: A controlled and enhanced silver staining method. An abstract submitted for the 17th Annual Meeting of the Society for Neuroscience. Soc Neurosci Abstr. 1987, 13: 189.9-
Google Scholar
Switzer RC, Campell SK, Murdock TM: A histolologic method for staining Alzheimer pathology. United States Patent #5192688. 1993
Google Scholar
Braak H, Thal DR, Ghebremedhin E, Del Tredici K: Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011, 70: 960-969. 10.1097/NEN.0b013e318232a379.
CAS
Article
PubMed
Google Scholar
Schönheit B, Zarski R, Ohm TG: Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology. Neurobiol Aging. 2004, 25: 697-711. 10.1016/j.neurobiolaging.2003.09.009.
Article
PubMed
Google Scholar
Czasch S, Paul S, Baumgärtner W: A comparison of immunohistochemical and silver staining methods for the detection of diffuse plaques in the aged canine brain. Neurobiol Aging. 2006, 27: 293-305. 10.1016/j.neurobiolaging.2005.02.017.
CAS
Article
PubMed
Google Scholar
Braak H, Braak E, Ohm T, Bohl J: Alzheimer's disease: mismatch between amyloid plaques and neuritic plaques. Neurosci Lett. 1989, 103: 24-28. 10.1016/0304-3940(89)90479-5.
CAS
Article
PubMed
Google Scholar
Quitschke WW: Curcuminoid binding to embryonal carcinoma cells: reductive metabolism, induction of apoptosis, senescence, and inhibition of cell proliferation. PLoS One. 2012, 7: e39568-10.1371/journal.pone.0039568.
PubMed Central
CAS
Article
PubMed
Google Scholar
Péret-Almeida L, Cherubino AP, Alves RJ, Dufossé L, Glória MB: Separation and determination of the physico-chemical characteristics of curcumin, demethoxycurcumin and bisdemethoxycurcumin. Food Res Int. 2005, 38: 1039-1044. 10.1016/j.foodres.2005.02.021.
Article
Google Scholar
Ireson CR, Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, Farmer PB, Steward WP, Gescher AJ: Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev. 2002, 11: 105-111.
CAS
PubMed
Google Scholar
Hoehle SI, Pfeiffer E, Sólyom AM, Metzler M: Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. J Agric Food Chem. 2006, 54: 756-764. 10.1021/jf058146a.
CAS
Article
PubMed
Google Scholar
Kim H, Park BS, Lee KG, Choi CY, Jang SS, Kim YH, Lee SE: Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid. J Agric Food Chem. 2005, 53: 8537-8541. 10.1021/jf051985c.
CAS
Article
PubMed
Google Scholar
Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR: Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to β-amyloid deposition and neurotransmitter abnormalities. Neurobiol Dis. 2005, 18: 602-617. 10.1016/j.nbd.2004.10.022.
CAS
Article
PubMed
Google Scholar
Munro IC, Newberne PM, Young VR, Bär A: Safety assessment of γ-cyclodextrin. Regul Toxicol Pharmacol. 2004, 39 (Suppl 1): S3-13.
CAS
Article
PubMed
Google Scholar
Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP: Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006, 24: 516-524. 10.1016/j.nbd.2006.08.017.
CAS
Article
PubMed
Google Scholar
Belkacemi A, Doggui S, Dao L, Ramassamy C: Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med. 2011, 13: e34-
Article
PubMed
Google Scholar
Perkins S, Verschoyle RD, Hill K, Parveen I, Threadgill MD, Sharma RA, Williams ML, Steward WP, Gescher AJ: Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev. 2002, 11: 535-540.
CAS
PubMed
Google Scholar
Ma Z, Shayeganpour A, Brocks DR, Lavasanifar A, Samuel J: High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed Chromatogr. 2007, 21: 546-552. 10.1002/bmc.795.
CAS
Article
PubMed
Google Scholar
Pan MH, Huang TM, Lin JK: Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos. 1999, 27: 486-494.
CAS
PubMed
Google Scholar
Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S, Jukes R, Williams M, Steward WP, Gescher A: Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res. 2001, 61: 1058-1064.
CAS
PubMed
Google Scholar
Holder GM, Plummer JL, Ryan AJ: The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica. 1978, 8: 761-768. 10.3109/00498257809069589.
CAS
Article
PubMed
Google Scholar
Asai A, Miyazawa T: Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000, 67: 2785-2793. 10.1016/S0024-3205(00)00868-7.
CAS
Article
PubMed
Google Scholar
Marczylo TH, Steward WP, Gescher AJ: Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric Food Chem. 2009, 57: 797-803. 10.1021/jf803038f.
CAS
Article
PubMed
Google Scholar