Smith HS, Smith AR, Seidner P: Painful rheumatoid arthritis. Pain Physician. 2011, 14: E427-E458.
PubMed
Google Scholar
McInnes IB, Schett G: The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011, 365: 2205-2219. 10.1056/NEJMra1004965.
Article
CAS
PubMed
Google Scholar
Chinopoulos C, Adam-Vizi V: Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J. 2006, 273: 433-450. 10.1111/j.1742-4658.2005.05103.x.
Article
CAS
PubMed
Google Scholar
Papa S: Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications. Biochim Biophys Acta. 1996, 1276: 87-105. 10.1016/0005-2728(96)00077-1.
Article
PubMed
Google Scholar
Quinn MT, Gauss KA: Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J Leukoc Biol. 2004, 76: 760-781. 10.1189/jlb.0404216.
Article
CAS
PubMed
Google Scholar
Cross AR, Segal AW: The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim Biophys Acta. 2004, 1657: 1-22. 10.1016/j.bbabio.2004.03.008.
PubMed Central
Article
CAS
PubMed
Google Scholar
Filippin LI, Vercelino R, Marroni NP, Xavier RM: Redox signalling and the inflammatory response in rheumatoid arthritis. Clin Exp Immunol. 2008, 152: 415-422. 10.1111/j.1365-2249.2008.03634.x.
PubMed Central
Article
CAS
PubMed
Google Scholar
Winyard PG, et al: Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans. 2011, 39: 1226-1232. 10.1042/BST0391226.
Article
CAS
PubMed
Google Scholar
Hadjigogos K: The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med. 2003, 45: 7-13.
CAS
PubMed
Google Scholar
Kasai H, et al: Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis. 1986, 7: 1849-1851. 10.1093/carcin/7.11.1849.
Article
CAS
PubMed
Google Scholar
Maki H, Sekiguchi M: MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 1992, 355: 273-275. 10.1038/355273a0.
Article
CAS
PubMed
Google Scholar
Ishibashi T, Hayakawa H, Sekiguchi M: A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO Rep. 2003, 4: 479-483. 10.1038/sj.embor.embor838.
PubMed Central
Article
CAS
PubMed
Google Scholar
Negishi H, et al: The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania. J Hypertens. 2001, 19: 529-533. 10.1097/00004872-200103001-00002.
Article
CAS
PubMed
Google Scholar
Nishikawa T, et al: Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes. Diabetes Care. 2003, 26: 1507-1512. 10.2337/diacare.26.5.1507.
Article
CAS
PubMed
Google Scholar
Shen J, et al: Telomere length, oxidative damage, antioxidants and breast cancer risk. International journal of cancer. Journal international du cancer. 2009, 124: 1637-1643. 10.1002/ijc.24105.
PubMed Central
Article
CAS
PubMed
Google Scholar
Bashir S, Harris G, Denman MA, Blake DR, Winyard PG: Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheum Dis. 1993, 52: 659-666. 10.1136/ard.52.9.659.
PubMed Central
Article
CAS
PubMed
Google Scholar
Miyamoto M, Kotani K, Ishibashi S, Taniguchi N: The relationship between urinary 8-hydroxydeoxyguanosine and metabolic risk factors in asymptomatic subjects. Medical principles and practice: international journal of the Kuwait University, Health Science Centre. 2011, 20: 187-190. 10.1159/000319774.
Article
Google Scholar
Masugata H, et al: Association between Urinary 8-Hydroxydeoxyguanosine, an Indicator of Oxidative Stress, and the Cardio-Ankle Vascular Index in Hypertensive Patients. J Atheroscler Thromb. 2012, 19: 747-755. 10.5551/jat.12716.
Article
CAS
PubMed
Google Scholar
Ohsawa I, et al: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007, 13: 688-694. 10.1038/nm1577.
Article
CAS
PubMed
Google Scholar
Gharib B, et al: Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. Comptes rendus de l'Academie des sciences. Serie III. Sciences de la vie. 2001, 324: 719-724.
CAS
PubMed
Google Scholar
Abraini JH, Gardette-Chauffour MC, Martinez E, Rostain JC, Lemaire C: Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol. 1994, 76: 1113-1118.
CAS
PubMed
Google Scholar
Fontanari P, et al: Changes in maximal performance of inspiratory and skeletal muscles during and after the 7.1-MPa Hydra 10 record human dive. Eur J Appl Physiol. 2000, 81: 325-328. 10.1007/s004210050050.
Article
CAS
PubMed
Google Scholar
Ohta S: Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des. 2011, 17: 2241-2252. 10.2174/138161211797052664.
PubMed Central
Article
CAS
PubMed
Google Scholar
Kajiyama S, et al: Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008, 28: 137-143. 10.1016/j.nutres.2008.01.008.
Article
CAS
PubMed
Google Scholar
Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N: Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010, 46: 140-149. 10.3164/jcbn.09-100.
PubMed Central
Article
PubMed
Google Scholar
Schellekens GA, et al: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000, 43: 155-163. 10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2–3.
Article
CAS
PubMed
Google Scholar
Van Gaalen FA, et al: Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum. 2004, 50: 2113-2121. 10.1002/art.20316.
Article
CAS
PubMed
Google Scholar
Seo T, Kurokawa R, Sato B: A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum. Medical gas research. 2012, 2: 1-10.1186/2045-9912-2-1.
PubMed Central
Article
PubMed
Google Scholar
Ito M, et al: Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Medical gas research. 2012, 2: 15-10.1186/2045-9912-2-15.
PubMed Central
Article
CAS
PubMed
Google Scholar
Saito S, et al: Quantitative determination of urinary 8-hydroxydeoxyguanosine (8-OH-dg) by using ELISA. Res Commun Mol Pathol Pharmacol. 2000, 107: 39-44.
CAS
PubMed
Google Scholar
Ghoshal UC: How to interpret hydrogen breath tests. Journal of neurogastroenterology and motility. 2011, 17: 312-317. 10.5056/jnm.2011.17.3.312.
PubMed Central
Article
PubMed
Google Scholar
Goebel KM, Storck U, Neurath F: Intrasynovial orgotein therapy in rheumatoid arthritis. Lancet. 1981, 1: 1015-1017.
Article
CAS
PubMed
Google Scholar
Salvemini D, Cuzzocrea S: Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine. rit Care Med. 2003, 31: S29-38. 10.1097/01.CCM.0000042468.64712.21.
Article
CAS
Google Scholar
Afonso V, Champy R, Mitrovic D, Collin P, Lomri A: Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine. 2007, 74: 324-329. 10.1016/j.jbspin.2007.02.002.
Article
CAS
PubMed
Google Scholar
Edaravone Acute Infarction Study Group: Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003, 15: 222-229.
Arii K, Kumon Y, Ikeda Y, Suehiro T, Hashimoto K: Edaravone inhibits the disease activity in rheumatoid arthritis. J Clin Pharm Ther. 2006, 31: 197-199. 10.1111/j.1365-2710.2006.00722.x.
Article
CAS
PubMed
Google Scholar
Buchholz BM, et al: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2008, 8: 2015-2024. 10.1111/j.1600-6143.2008.02359.x.
Article
CAS
Google Scholar
Suzuki YJ, Forman HJ, Sevanian A: Oxidants as stimulators of signal transduction. Free Radic Biol Med. 1997, 22: 269-285. 10.1016/S0891-5849(96)00275-4.
Article
CAS
PubMed
Google Scholar
Finkel T: Oxygen radicals and signaling. Curr Opin Cell Biol. 1998, 10: 248-253. 10.1016/S0955-0674(98)80147-6.
Article
CAS
PubMed
Google Scholar
Qin ZX, et al: Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway. Atherosclerosis. 2012, 220: 343-350. 10.1016/j.atherosclerosis.2011.11.002.
Article
CAS
PubMed
Google Scholar
Ishibashi T, et al: Mammalian enzymes for preventing transcriptional 598 errors caused by oxidative damage. Nucleic Acids Res. 2005, 33: 3779-3784. 10.1093/nar/gki682.
PubMed Central
Article
CAS
PubMed
Google Scholar
Bang H, et al: Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 2007, 56: 2503-2511. 10.1002/art.22817.
Article
CAS
PubMed
Google Scholar
Remans PH, et al: Clinical, Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 2005, 52: 2003-2009. 10.1002/art.21111.
Article
CAS
PubMed
Google Scholar
Breedveld FC, Combe B: Understanding emerging treatment paradigms in rheumatoid arthritis. Arthritis Res Ther. 2011, 13 (Suppl 1): S3-10.1186/1478-6354-13-S1-S3.
PubMed Central
PubMed
Google Scholar
Davila L, Ranganathan P: Pharmacogenetics: implications for therapy in rheumatic diseases. Nat Rev Rheumatol. 2011, 7: 537-550. 10.1038/nrrheum.2011.117.
Article
CAS
PubMed
Google Scholar
Mitchell KL, Pisetsky D: Early rheumatoid arthritis. Curr Opin Rheumatol. 2007, 19: 278-283. 10.1097/BOR.0b013e32805e87bf.
Article
PubMed
Google Scholar
Dougados M, et al: Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY). Ann Rheum Dis. 2012, 10.1136/annrheumdis-2011-201282.
Google Scholar
Kavanaugh A, et al: Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study. Ann Rheum Dis. 2012, 33: 3779-3784. 10.1136/annrheumdis-2011-201247.
Google Scholar
Detert J, et al: Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study. Ann Rheum Dis. 2012, 10.1136/annrheumdis-2012-201612. Jul 7. [Epub ahead of print]
Google Scholar