Background

Septo-optic dysplasia (SOD) is a heterogeneous malformation condition consisting of optic nerve hypoplasia, various types of forebrain defects and hormonal deficiencies. This study aims to expand knowledge about endocrine abnormalities in patients with SOD in ASEAN countries.

Material and method

Forty-eight patients (27 male, 21 female) who has been diagnosed as having SOD in ASEAN countries were clinically reviewed from medical records.

Results

Clinical manifestations and endocrine abnormalities of the patients are shown in Table 1

Table 1 Clinical manifestation of SOD patients
Full size table

Conclusion

This multicenter and multinational study shows that about 20-35 % of SOD patients have endocrine abnormalities. Hypothyroidism and GH insufficiency are the most common endocrine problems associated with this condition.