A 78-year-old woman presented with an altered level of consciousness and sudden onset of right-sided weakness. She was stuporous and there was severe weakness of the right limbs (right upper limb weakness of grade 1 and right lower limb weakness of grade 1; National Institute of Health Stroke Scale (NIHSS) score, 16 points). The time from the onset of the symptoms to the arrival at our hospital was 90 minutes. She had cardiac surgery for atrial septal defect with pulmonary valve stenosis 40 years ago. She did not a medical history of hypertension, diabetes mellitus or dyslipidemia. Emergency computed tomography (CT) and CT angiography of brain confirmed an occlusion of the upper segment of the basilar artery (BA) and the right and left posterior cerebral arteries (PCAs) due to thrombus formation. Thrombolytic therapy with a standard dose of IV tPA (0.9 mg/kg body weight) was promptly commenced. However, there weren’t any clinical improvements in the patient’s condition until the end of tPA infusion; therefore, intra-arterial (IA) thrombectomy with a Penumbra catheter was performed. With a right femoral approach, a dose of unfractionated heparin (1500 units) was intravenously administered and cerebral angiography was performed; complete occlusion of the distal BA was observed. A Penumbra catheter with a Prowler108 catheter was inserted into the distal portion of the BA through the right vertebral artery. Mechanical thrombectomy via the Penumbra catheter was performed with manual suction. After successful recanalization with this procedure, the patient’s symptoms dramatically improved: the NIHSS score improved to 3 points.
However, after an hour, the patient suddenly complained of severe abdominal pain. Physical examination revealed the presence of an acutely enlarged mass on the left side of the abdominal wall. The patient’s blood pressure was 120/80 mmHg and the heart rate was 102/min. Blood tests revealed hemoglobin of 11.7 g/dL, hematocrit of 35.4% and platelet count of 205,000/mm3. Contrast-enhanced abdominal and pelvic CT image demonstrated a large intramuscular abdominal wall hematoma and active contrast extravasation within the hematoma, which was considered to be the focus of active bleeding (Figure 1). To prevent further bleeding, selective arteriography was performed and the left inferior epigastric artery was identified as the source of active bleeding. The proximal part of the bleeding artery was embolized with polyvinyl alcohol (250 μm), and the mixture of histoacryl and lipiodril (Figure 2). After the embolization, the patient stopped complaining of abdominal pain, and the abdominal wall hematoma stopped growing in size. During the rest of the hospitalization, her vital signs and hemoglobin level remained stable. On the 14th day, the patient was discharged home because she acquired a complete functional independence with only mild dysarthria (NIHSS score at the time of discharge was 1).
Vascular interventions such as IA thrombectomy can cause vascular rupture and bleeding. However, in this case, the IA procedure was performed via the right femoral artery, and the bleeding occurred from the left epigastric artery, which had originated from the left external iliac artery; therefore, it was likely to be related to the IV thrombolysis. Abdominal wall hematoma has been rarely reported in patients with deep vein thrombosis who underwent IV thrombolysis or long-term low-molecular-weight heparin therapy [11, 12]. To the best of our knowledge, this is the first description of a case of active bleeding from the abdominal wall associated with thrombolysis for ischemic stroke.