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Granulocyte Colony-Stimulating Factor Administration for Infertile Women With Thin Endometrium in Frozen Embryo Transfer Program

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Abstract

We aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) administration for infertile women with thin endometrium in frozen embryo transfer program. Among 59 infertile patients with thin endometrium (<7 mm), 34 patients received uterine infusion of recombinant human G-CSF (100 µg/0.6 mL) on the day of ovulation or administration of progesterone or human chorionic gonadotropin, with 40 cycles defined as G-CSF group and 49 previous cycles as self-controlled group, and 25 patients refused, with 80 cycles defined as the control group. Higher proportion of induced cycles and lower proportion of natural cycles were observed in the G-CSF group, when compared to the self-controlled group or control group (P <.05). The cycle cancellation rate was, in descending order, 69.39% in self-controlled group, 48.75% in control group, and 17.50% in G-CSF group, with significant difference (P <.05). The implantation rate and clinical pregnancy rate per embryo transfer were similar in all the groups (P >.05). Our study fails to demonstrate that G-CSF has the potential to improve embryo implantation and clinical pregnancy rate of the infertile women with thin endometrium.

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Authors and Affiliations

  1. Department of Reproductive Medicine, Guangdong Provincial Family Planning Research Institute, Guangzhou, Guangdong, China

    Ping Pan MMed

  2. Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, 107 West Yan Jiang Road, Guangzhou, Guangdong, 510120, China

    Yu Li MD, PhD, Ping Pan MMed, Xiaoli Chen MD, PhD, Lin Li MD, PhD, Yi Li MD, PhD & Dongzi Yang MD, PhD

Authors
  1. Yu Li MD, PhD
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  2. Ping Pan MMed
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  3. Xiaoli Chen MD, PhD
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  4. Lin Li MD, PhD
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  5. Yi Li MD, PhD
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  6. Dongzi Yang MD, PhD
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Correspondence to Dongzi Yang MD, PhD.

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Li, Y., Pan, P., Chen, X. et al. Granulocyte Colony-Stimulating Factor Administration for Infertile Women With Thin Endometrium in Frozen Embryo Transfer Program. Reprod. Sci. 21, 381–385 (2014). https://doi.org/10.1177/1933719113497286

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  • DOI: https://doi.org/10.1177/1933719113497286

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