Abstract
Objective
To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles.
Study Design
This is a hospital-based prospective study.
Patients
Thirty-five women with persistent thin endometrium (<7 mm) resistant to standard treatments were involved in this study.
Intervention(s)
Intrauterine infusion of GCSF (300 mcg/1 ml) was done in patients with thin endometrium on day 14 of FET cycles, and their endometrial thicknesses were measured after 48 h of infusion.
Main Outcome Measures
The primary outcome was an increase in endometrial thickness and the secondary outcome measures were chemical and clinical pregnancies.
Results
The endometrial thickness increased from 5.86 ± 0.58 to 6.58 ± 0.84 mm after GCSF infusion. In 19 of the 35 participants (54.28 %) endometrial thickness increased to ≥7 mm and they subsequently underwent embryo transfer. Of these, 3 (15.78 %) patients had chemical pregnancy, but there was no clinical pregnancy. In 16 participants, embryo transfer was canceled in view of insufficient endometrial thickness (<7 mm).
Conclusion
GCSF caused a small increase in endometrial thickness in women with persistent thin endometrium, but there was no improvement in their pregnancy rates.
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Vineet Mishra, Sumesh Choudhary, Urmila Sharma, Rohina Aggarwal, Ritu Agarwal, Khushali Gandhi, and Nilesh Goraniya declare that they have no conflicts of interest.
Informed consent
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study.
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Vineet Mishra is a Professor and Head; Sumesh Choudhary is an Assistant Professor; Urmila Sharma is a Fellow; Rohina Aggarwal is an Associate Professor; Ritu Agarwal is a Fellow; Khushali Gandhi is a Fellow; Nilesh Goraniya is a Fellow at the Department of Obstetrics and Gynecology Institute of Kidney Disease and Research Centre – Institute of Transplantation Sciences, Civil Hospital, Ahmedabad, India.
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Mishra, V.V., Choudhary, S., Sharma, U. et al. Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles. J Obstet Gynecol India 66 (Suppl 1), 407–411 (2016). https://doi.org/10.1007/s13224-015-0775-9
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DOI: https://doi.org/10.1007/s13224-015-0775-9