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Association Between Body Weight at Weaning and Remodeling in the Subcutaneous Adipose Tissue of Obese Adult Mice With Undernourishment In Utero

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Abstract

Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of body weight at weaning (19.5 days) positively correlated with parameters of obesity, metabolic disorders, and remodeling of subcutaneous adipose tissue, such as numbers of macrophages in adipose tissue, the ratio of inflammatory M1 to anti-inflammatory M2 macrophages, estimated by gene expression of specific antigens, and the relative ratio of small adipocytes less than 30 mm in diameter, on a high-fat diet at 17 weeks of age. To our knowledge, this is the first report of a possible connection between infantile body weight and adipose tissue remodeling in obesity after undernourishment in utero.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan

    Yukiko Kobayashi Kohmura MD, Naohiro Kanayama MD, PhD, Keiko Muramatsu MD, Naoaki Tamura MD, PhD, Chizuko Yaguchi MD, Toshiyuki Uchida MD, PhD, Kazunao Suzuki MD, PhD, Kazuhiro Sugihara MD, PhD & Hiroaki Itoh MD, DMed, Sci

  2. Department of Home Economics, Otsuma Women’s University, Tokyo, Japan

    Seiichiro Aoe PhD

  3. Department of Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Takeshi Sasaki PhD

  4. Department of Molecular Medicine Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Takayoshi Suganami MD, PhD & Yoshihiro Ogawa MD, PhD

  5. Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan

    Yoshihiro Ogawa MD, PhD

Authors
  1. Yukiko Kobayashi Kohmura MD
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  2. Naohiro Kanayama MD, PhD
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  7. Kazunao Suzuki MD, PhD
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  8. Kazuhiro Sugihara MD, PhD
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  11. Takayoshi Suganami MD, PhD
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  12. Yoshihiro Ogawa MD, PhD
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  13. Hiroaki Itoh MD, DMed, Sci
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Corresponding author

Correspondence to Hiroaki Itoh MD, DMed, Sci.

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Kohmura, Y.K., Kanayama, N., Muramatsu, K. et al. Association Between Body Weight at Weaning and Remodeling in the Subcutaneous Adipose Tissue of Obese Adult Mice With Undernourishment In Utero. Reprod. Sci. 20, 813–827 (2013). https://doi.org/10.1177/1933719112466300

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