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Plasma Hemopexin as a Potential Regulator of Vascular Responsiveness to Angiotensin II

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Abstract

This brief review focuses on the functional activities of plasma hemopexin recently recognized by several authors. In particular, the protease-like activity of hemopexin in vitro is linked with downregulation of the vascular angiotensin II receptor in vivo, leading to vascular expansion. Also a potential mechanism of inhibition of hemopexin activity by extracellular adenosine triphosphate is considered.

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References

  1. Grabar P, de Vaux St-Cyr C, Cleve H. Presence of β1-B globulin in the perchloric acid extracts of human normal serums. Bull Soc Chim Biol. 1960;42:853–856.

    CAS  PubMed  Google Scholar 

  2. Immenschuh S, Song DX, Satoh H, Muller-Eberhard U. The type II hemopexin interleukin-6 response element predominates the transcriptional regulation of the hemopexin acute phase responsiveness. Biochem Biophys Res Commun. 1995;207(1):202–208.

    Article  CAS  Google Scholar 

  3. Morgan WT, Smith A. Binding and transport of iron-porphyrins by hemopexin. Adv Inorg Chem. 2001;51:205–241.

    Article  CAS  Google Scholar 

  4. Delanghe JR, Langois MR. Hemopexin: a review of biological aspects and the role in laboratory medicine. Clin Chim Acta. 2001;312(1–2):13–23.

    Article  CAS  Google Scholar 

  5. Tolosano E, Fagonee S, Morello M, Vinchi F, Fiorito V. Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal. 2010;12(2):305–320.

    Article  CAS  Google Scholar 

  6. Marchot P, Chatonnet A. Enzymatic activity and protein interactions in alpha/beta hydrolase fold proteins: moonlighting versus promiscuity. Protein Pept Lett. 2012;19(2):132–143.

    Article  CAS  Google Scholar 

  7. Sogorb MA, Diaz-Alejo N, Escudero MA, Vilanova E. Phosphotriesterase activity identified in purified serum albumins. Arch Toxicol. 1998;72(4):219–226.

    Article  CAS  Google Scholar 

  8. Suzuki K, Kato H, Sakuma Y, Namiki H. Hemopexins suppress phorbol ester-induced necrosis of polymorphonuclear leucocytes. Cell Struct Funct. 2001;26(4):235–241.

    Article  CAS  Google Scholar 

  9. Suzuki K, Kobayashi N, Doi T, Hijikata T, Machida I, Namiki H. Inhibition of Mg2+ dependent adhesion of polymorphonuclear leucocytes by serum hemopexin: differences in divalent-cation dependency of cell adhesion in the presence and absence of serum. Cell Struct Funct. 2003;28(4):243–253.

    Article  CAS  Google Scholar 

  10. Liang X, Lin T, Sun G, Beasley-Topliffe L, Cavaillon JM, Warren HS, Warren HS. Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol. 2009; 86(2):229–235.

    Article  CAS  Google Scholar 

  11. Cheung PK, Stulp B, Immenschuh S, Borghuis T, Baller JF, Bakker WW. Is 100KF an isoform of hemopexin? Immunochemical characterization of the vasoactive plasma factor 100KF. J Am Soc Nephrol. 1999;10(8):1700–1708.

    CAS  PubMed  Google Scholar 

  12. Bakker WW, Borghuis T, Harmsen MC, et al. Protease activity of plasma hemopexin. Kidney Int. 2005;68(2):603–610.

    Article  CAS  Google Scholar 

  13. Mangan MS, Kaiseman D, Bird PI. The role of serpins in vertebrate immunity. Tissue Antigens. 2008;72(1):1–10.

    Article  CAS  Google Scholar 

  14. Colman RW. Contact activation pathway: inflammatory, fibrinolytic, anticoagulant, anti-adhesive and anti-angiogenic activities. In: Coman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Hemostasis and Thrombosis; Basic Principles and Clinical Practice. 4th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:103–121.

    Google Scholar 

  15. Bakker WW, Henning RH, van Son WJ, et al. Vascular contraction and preeclampsia: down-regulation of the angiotensin receptor 1 by hemopexin in vitro. Hypertension. 2009;53(6):959–964.

    Article  CAS  Google Scholar 

  16. Bakker WW, Donker RB, Timmer A, et al. Plasma hemopexin activity in pregnancy and preeclampsia. Hypertens Pregnancy. 2007;26(2):227–239.

    Article  CAS  Google Scholar 

  17. Spiller F, Costa C, Souto FO, et al. Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice. Am J Respir Crit Care Med. 2011;183(7):922–931.

    Article  CAS  Google Scholar 

  18. Grant NF, Daley GL, Chand S, Whalley PJ, MacDonald PC. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest. 1973;52(11):2682–2689.

    Article  Google Scholar 

  19. Mitchell RN, Schoen J. Blood vessels. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. The Pathologic Basis of Diseases. Philadelphia, Pa: Saunders Elsevier; 2010:487–529.

    Chapter  Google Scholar 

  20. Cheung PK, Klok PA, Bakker WW. Minimal change-like glomerular alterations induced by a human plasma factor. Nephron. 1996;74(3):586–593.

    Article  CAS  Google Scholar 

  21. Bakker WW, van Dael CM, Pierik LJ, et al. Altered activity of plasma hemopexin in patients with minimal change disease in relapse. Pediatr Nephrol. 2005;20(10):1410–1415.

    Article  Google Scholar 

  22. Cheung PK, Klok PA, Baller JF, Bakker WW. Induction of experimental proteinuria in vivo following infusion of human plasma hemopexin. Kidney Int. 2000;57(4):1512–1520.

    Article  CAS  Google Scholar 

  23. Kapojos JJ, Poelstra K, Borghuis T, Banas B, Bakker WW. Regulation of plasma hemopexin activity by stimulated endothelial or mesangial cells. Nephron Physiol. 2004;96(1):1–10.

    Article  Google Scholar 

  24. Mauk MR, Smith A, Mauk AG. An alternative view of the proposed alternative activities of hemopexin. Protein Sci. 2011; 20(5):791–805.

    Article  CAS  Google Scholar 

  25. Dunker AK, Kriwacki RW. The orderly chaos of proteins. Sci Am. 2011;304(4):68–73.

    Article  CAS  Google Scholar 

  26. Chouard T. Breaking the protein rules. Nature. 2011;471(7337): 151–153.

    Article  CAS  Google Scholar 

  27. Wang Y, Fisher JC, Mathew R, et al. Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21. Nat Chem Biol. 2011;7(4):214–221.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, PO Box 30001, Groningen, 9700RB, The Netherlands

    Winston W. Bakker PhD, Floor Spaans MSc, Theo Borghuis BSc, Harry van Goor PhD & Marijke M. Faas PhD

  2. Pediatric Nephrology, VU University Medical Center, Amsterdam, The Netherlands

    Loubna el Bakkali MD

  3. Pepscan Therapeutics BV, Lelystad, The Netherlands

    Evert van Dijk PhD & Joshua Buijnink PhD

Authors
  1. Winston W. Bakker PhD
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  2. Floor Spaans MSc
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  3. Loubna el Bakkali MD
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  4. Theo Borghuis BSc
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  5. Harry van Goor PhD
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  6. Evert van Dijk PhD
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  7. Joshua Buijnink PhD
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  8. Marijke M. Faas PhD
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Correspondence to Winston W. Bakker PhD.

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Bakker, W.W., Spaans, F., el Bakkali, L. et al. Plasma Hemopexin as a Potential Regulator of Vascular Responsiveness to Angiotensin II. Reprod. Sci. 20, 234–237 (2013). https://doi.org/10.1177/1933719112446081

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  • DOI: https://doi.org/10.1177/1933719112446081

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