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The Association Between Maternal Oxidative Stress at Mid-Gestation and Subsequent Pregnancy Complications

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Abstract

Objective

To investigate the association between maternal oxidative stress at mid-gestation and subsequent development of pregnancy complications.

Study design

A total of 503 healthy pregnant women provided their blood and urine samples at 24 to 26 weeks of gestation and were prospectively followed through postpartum. These samples were used to assess a variety of oxidative stress markers, including plasma total antioxidant capacity, 8-isoprostane, erythrocyte glutathione peroxidase and superoxide dismutase activity, and urinary 8-hydroxydeoxyguanosine (8-OHdG).

Results

Compared with women with uncomplicated pregnancies, significantly higher plasma 8-isoprostane levels were noted in women who developed preeclampsia (P = .008) and small-for-gestational age infants (P = .002), while higher urinary 8-OHdG concentrations were noted in women who subsequently had low-birth-weight neonates (<2500 g, P = .043).

Conclusion

Increased maternal oxidative stress at mid-gestation was associated with subsequent pregnancy complications.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei, 199 Dun-hua North Road, Taipei, 105, Taiwan

    T’sang-T’ang Hsieh MD, Liang-Ming Lo MD, Meng-Jen Li BA, Yi-Lin Yeh MS & Tai-Ho Hung MD, PhD

  2. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei, Tao-yuan, Taiwan

    Tai-Ho Hung MD, PhD

  3. Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan

    Szu-Fu Chen MD, PhD

Authors
  1. T’sang-T’ang Hsieh MD
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  2. Szu-Fu Chen MD, PhD
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  3. Liang-Ming Lo MD
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  4. Meng-Jen Li BA
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  5. Yi-Lin Yeh MS
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  6. Tai-Ho Hung MD, PhD
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Corresponding author

Correspondence to Tai-Ho Hung MD, PhD.

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Hsieh, TT., Chen, SF., Lo, LM. et al. The Association Between Maternal Oxidative Stress at Mid-Gestation and Subsequent Pregnancy Complications. Reprod. Sci. 19, 505–512 (2012). https://doi.org/10.1177/1933719111426601

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  • DOI: https://doi.org/10.1177/1933719111426601

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