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The Associations Between Maternal and Fetal Angiotensinogen M235T Polymorphism and Pregnancy-Induced Hypertension in Chinese Women

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Abstract

This study was to investigate whether the maternal and fetal angiotensinogen (AGT) M235T polymorphism were associated with the risk of pregnancy-induced hypertension (PIH) in Chinese Han ethnic women. Using a case-control mother-baby dyads study, a total of 226 maternal/offspring pairs were recruited at Anyang Maternal and Child Health Hospital from January 2008 to December 2009. Genomic DNA was extracted from maternal venous and cord blood. We genotyped the AGT M235T polymorphism by using PCR-RFLP assay and examined the association with PIH using logistic regression analysis. In the current study, the maternal AGT M235T polymorphism showed no effect on the risk of PIH (P =.786) while the fetal AGT M235T polymorphism is significantly associated with PIH in Chinese Han ethnic women (P =.004). The fetus carrying TT genotype is a protective factor in developing PIH in the study population (OR =.28, 95% CI =.14–0.59).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science & Technology, Hangkong Road 13, 430030, Wuhan, China

    Pan Xiang MMed, Shaofa Nie Prof & Weirong Yan PhD

  2. Maternal and Child Health Hospital of Anyang City, Anyang City, China

    Zhiwei Li MD & Haihong Di MD

  3. Division of Global Health (IHCAR), Karolinska Institute, Stockholm, Sweden

    Weirong Yan PhD

Authors
  1. Pan Xiang MMed
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  2. Zhiwei Li MD
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Correspondence to Weirong Yan PhD.

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Xiang, P., Li, Z., Di, H. et al. The Associations Between Maternal and Fetal Angiotensinogen M235T Polymorphism and Pregnancy-Induced Hypertension in Chinese Women. Reprod. Sci. 18, 640–644 (2011). https://doi.org/10.1177/1933719110395405

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