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Exercise-induced Changes in Venous Vascular Function in Nonpregnant Formerly Preeclamptic Women

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Abstract

Objective

Formerly preeclamptic women with low plasma volume are at increased risk of recurrent gestational hypertensive disease. We hypothesized that a 4-week cycling training in formerly preeclamptic women improves (venous) hemodynamic function.

Methods

In 9 formerly preeclamptic women, we examined physical fitness and hemodynamic function, before and after the training. We assessed blood pressure, heart rate, cardiac output, plasma volume, and calf and forearm venous compliance.

Results

After the training, baseline blood pressure and cardiac output remained unchanged, but resting heart rate decreased (–7%, P = .02). Plasma volume was 8% higher after training (P = .01). Calf venous compliance increased (+18%, P = .02) but not forearm venous compliance (+14%, P = .09).

Conclusion

Cycling training improves venous vascular function in formerly preeclamptic women. The decreased resting heart rate and improvement of venous compliance suggest reduced sympathetic activity. These rapid exercise-induced changes may improve maternal vascular adaptation in early pregnancy and with it the risk of (recurrent) gestational hypertensive disease.

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, Physiology, and Nuclear Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, 9101, 791, Nijmegen, The Netherlands

    Ineke Krabbendam MD, Martje L. Maas MD, Wim J. G. Oyen MD, PhD, Fred K. Lotgering MD, PhD, Maria T. E. Hopman MD, PhD & Marc E. A. Spaanderman MD, PhD

  2. Research Institute for Sport and Exercise Science, John Moores University, Liverpool, United Kingdom

    Dick H. J. Thijssen PhD

Authors
  1. Ineke Krabbendam MD
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  2. Martje L. Maas MD
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  3. Dick H. J. Thijssen PhD
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  4. Wim J. G. Oyen MD, PhD
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  5. Fred K. Lotgering MD, PhD
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  6. Maria T. E. Hopman MD, PhD
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  7. Marc E. A. Spaanderman MD, PhD
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Correspondence to Ineke Krabbendam MD.

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Krabbendam, I., Maas, M.L., Thijssen, D.H.J. et al. Exercise-induced Changes in Venous Vascular Function in Nonpregnant Formerly Preeclamptic Women. Reprod. Sci. 16, 414–420 (2009). https://doi.org/10.1177/1933719109332091

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