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Preeclampsia Prevention and Management

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Abstract

Preclampsia is a multisystem disorder specific to pregnancy with a high maternal and perinatal morbidity and mortality. The cause of this disorder is unknown. Preeclampsia likely represents the clinical end point of multiple contributory factors, and it is unlikely that any single cause will be found. The blueprint for the development of preeclampsia is laid down early in pregnancy, and delivery of the fetus and placenta remains the only effective treatment. Efforts to prevent preeclampsia in women at high risk have been largely unsuccessful. Until the pathogenesis of preeclampsia is well defined, it is unlikely that effective preventive strategies will be developed.

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Authors and Affiliations

  1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, Massachusetts, USA

    Errol R. Norwitz MD, PhD & John T. Repke MD

  2. Department of Obstetrics and Gynecology, University of Nebraska Medical Center, University of Nebraska Medical School, Omaha, Nebraska, USA

    Errol R. Norwitz MD, PhD & John T. Repke MD

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  1. Errol R. Norwitz MD, PhD
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  2. John T. Repke MD
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Correspondence to Errol R. Norwitz MD, PhD.

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Supported in part by the Reproductive Scientist Development Program through National Institutes of Health grant no. 5K12-HD00849 and the Association of Professors of Obstetrics and Gynecology (to ERN).

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Norwitz, E.R., Repke, J.T. Preeclampsia Prevention and Management. Reprod. Sci. 7, 21–36 (2000). https://doi.org/10.1177/107155760000700105

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