Abstract
The quality of so-called 'natural medicines' is extraordinarily variable. Lack of resolute pharmacological assays contributes to this hiatus. More stringent evaluation of anti-inflammatory and anti-pyretic activities in rats can help resolve some of the uncertainties surrounding (a) preparations of some herbal products including so-called 'nature's aspirin' (e.g. willowbark, ginger), cat's claw, celery seed, etc., and (b) some animal lipids (e.g. Lyprinol® (NZ Mussel), emu and fish oils). These animal products can be a remarkable resource for supplementing conventional/allopathic therapy for inflammatory disease, e.g. providing lipoxygenase inhibitors. Beyond the verifiable science, the healing professions and the general public still need to examine more carefully criteria for QUALITY(S) in any alternative medicine—to ensure the good (= both reputations and products) are not destroyed by the bad—in essence counteracting Gresham's Law which states: the bad tends to displace the good.
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REFERENCES
Altman, R. D. and Marcussen, K. C. (2001). Effects of a ginger extract on knee pain in patients with osteoarthritis, Arthritis Rheum. 44, 2531–2538.
Amin, A. R., Vyas, P., Attur, M. et al. (1995). The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase, Proc. Natl. Acad. Sci. USA 92, 7926–7930.
Bliddal, H., Rosetzky, A., Schlichting, P. et al. (2000). A randomized, placebo-centrolled, cross-over study of ginger extract and Ibuprofen in osteoarthritis, Osteoarthritis Cartilage 8, 9–12.
Buchanan, W. W. and Kean, W. F. (2002). The treatment of acute rheumatism by salicin by T. J. Maclagan — The Lancet, 1876, J. Rheumatol. 29, 1321–1323.
Caughey, D. E., Grigor, R. R., Caughey, E. R. et al. (1983). Perna canaliculus in the treatment of rheumatoid arthritis, Eur. J. Rheumatol. Inflamm. 6, 197–200.
Desai, H. G., Kalro, R. H. and Choksi, A. P. (1990). Effect of ginger and garlic on DNA content of gastric aspirate, Ind. J. Med. Res. 92, 139–141.
Duke, J. A. (2000). Forward to Mills and Bone. Principles and Practice of Phytotherapy: Modern Herbal Medicine, pp. viii–ix. Churchill Livingstone, Edinburgh.
Ernst, E. and Chrubasik, S. (2000). Phyto-anti-inflammatories: a systemic review of randomised, placebo-control doubleblind trials, Rheum. Dis. Clin. N. Am. 26, 13–28.
Ernst, E., ed., with Pittler, M. H., Stevinson, C., White, A. (Assoc. Eds) (2001). The Desktop Guide to Complementary and Alternative Medicines: an Evidence-Based Approach, 444 pp. Moseby, Edinburgh.
Gibson, R. G. and Gibson, S. L. M. (1981). Green lipped mussel extract in arthritis, Lancet, 149.
Gibson, S. L. M. and Gibson, R. G. (1998). Treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial, Compl. Ther. Med. 6, 122–126.
Hung, D. Y., Mellick, G. D., Masci, P. P. et al. (1998). Focussed anti-thrombotic therapy: novel anti-platelet salicylates with reduced ulcerogenic potential and higher first pass detoxification than aspirin in rats, J. Lab. Clin. Med. 132, 469–277.
Huskisson, E. C., Scott, J. and Bryans, R. (1981). Seatone is ineffective in rheumatoid arthritis, Br. Med. J. 262, 1358–1359.
Jones, B. and Dixon, M. V. (1989). The Macmillan dictionary of biography, 3rd edn, p. 363. Macmillan, Melbourne.
Koo, K. L. K., Ammit, A. J., Tran, V. H. et al. (2001). Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation, Thromb. Res. 103, 387–397.
Larkin, J. G., Capell, H. A. and Sturrock, R. D. (1985). Seatone in rheumatoid arthritis: a six-month placebo-controlledstudy, Ann. Rheum. Dis. 44, 199–201.
Lipsey, R. G., Langley, P. C., Mahoney, D. M. (1985). Positive economics for Australian students, 2nd edn, pp. 679–680. Weidenfeld and Nicolson, London.
Merck Index (2001). 13th edn, p. 871. Merck, Whitehouse Station, N.J.
Mills, S. and Bone, K. (2000). Principles and Practice of Phytotherapy: Modern Herbal Medicine, pp. 139, 396–397. Churchill Livingstone, Edinburgh.
Parke, D. V., Symons, A. M. and Parke, A. L. (1989). Oxyradicals, inflammation and drugs acting on oxyradical production, in: New Developments in Antirheumatic Therapy, K. D. Rainsford and G. P. Velo (Eds), pp. 187–206. Kluwer Academic Publishers, Dordrecht.
Rainsford, K. D. (1984). Aspirin and the salicylates, pp. 1–12. Butterworths, London.
Schwartz, J. I., Chan, C. C., Mukhopadhyay, S. et al. (1999). Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans, Clin. Pharmacol. Ther. 65, 653–660.
Snowden, J. M. and Whitehouse, M. W. (1997). Anti-inflammatory activity of emu oils in rats, Inflammopharmacology 5, 127–132.
Warner, T. D., Giuliano, F., Vojnovic, I. et al. (1999). Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis, Proc. Natl. Acad. Sci. USA 96, 7563–7568.
Whitehouse, M. W. and Butters, D. E. (1999). Non-NSAID over-the counter (OTC) remedies for arthritis: good, bad or indifferent? Inflammopharmacology 7, 227–247.
Whitehouse, M. W., Roberts, M. S. and Brooks, P. M. (1999). Over the counter (OTC) remedies for arthritis and rheumatism: how effective are they? Inflammopharmacology 7, 89–105.
Wu, K. K., Sanduja, R., Tsai, A. et al. (1991). Aspirin inhibits interleukin 1-induced protaglandin H synthase expression in cultured endothelial cells, Proc. Natl. Acad. Sci. USA 88, 2384–2387.
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Butters, D.E., Whitehouse, M.W. Treating inflammation: some (needless) difficulties for gaining acceptance of effective natural products and traditional medicines. Inflammopharmacology 11, 97–110 (2003). https://doi.org/10.1163/156856003321547149
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DOI: https://doi.org/10.1163/156856003321547149