Abstract
Acetic acid ulcer models remain popular because of the simplicity of the procedures, the reliability of development, and a strong resemblance to human ulcers in terms of both pathology and healing processes. Such ulcer models, however, possess the drawback of invariable adherence of the ulcer base to the liver. The present study demonstrates the production of new acetic acid ulcer, i.e., a single ulcer per stomach with bases that do not adhere to the liver. This new model will prove useful for both screening antiulcer medications and elucidating the mechanisms underlying ulcer healing.
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REFERENCES
Amagase, K. and Okabe, S. (1999). A new ulcer model, ‘unhealed gastric ulcers’, induced by chronic treatment with indomethacin in rats with acetic acid ulcers, J. Physiol. Pharmacol. 50, 169–181.
Amagase, K., Ikeda, K. and Okabe, S.(1999). Antisecretory and ulcer healing effects of S-0509, a novel CCK-B/ gastrin receptor antagonist, in rats, Dig. Dis. Sci. 44, 879–888.
Hirose, H., Takeuchi, K. and Okabe, S. (1991). Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats, Gastroenterology 100, 1259–1265.
Keto, Y., Ebata, M., Tomita, K., et al. (2002). Influence of Helicobacter pylori infection on the healing and relapse of acetic acid ulcers in Mongolian gerbils, Dig. Dis. Sci. 47, 837–849.
Li, T. and Okabe, S. (1998). Effects of clarithromycin, omeprazole and leminoprazole on gastric ulcer healing in Helicobacter pylori-infected rats, J. Gastroenterol. Hepatol. 13, S185–S189.
Okabe, S., Roth, J. L. A. and Pfeiffer, C. J. (1971). A method for experimental, penetrating gastric and duodenal ulcers in rats, Am. J. Dig. Dis. 16, 277–284.
Okabe, S., Takagi, K. and Inoue, K. (1993). Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats, Jpn. J. Pharmacol. 62, 25–33.
Okabe, S., Nozue, C. and Amagase, K. (1997). Mechanism by which omeprazole and leminoprazole enhance healing of acetic acid gastric ulcers in rats: role of circulating gastrin, in: Gastroduodenal Mucosal Damage: Problems of Protection and Healing, R. Cheli, G. Iaquinto, S. Szabo (Eds), pp. 169–182. Mediserve, Napoli.
Takagi, K., Okabe, S. and Saziki, R. (1969). A new method for the production of chronic gastric ulcers in rats and the effects of several drugs on their healing, Jpn. J. Pharmacol. 69, 418–426.
Tsukimi, Y. and Okabe, S. (1994a). Effect of anterior unilateral vagotomy on healing of kissing gastric ulcers induced in rats, Jpn. J. Pharmacol. 66, 105–114.
Tsukimi, Y. and Okabe, S. (1994b). Validity of kissing gastric ulcers induced in rats for screening of antiulcer drugs, J. Gastroenterol. Hepatol. 9, S60–S65.
Tsukimi, Y., Nozue, C. and Okabe, S. (1996). Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats, J. Gastroenterol. Hepatol. 11, 335–340.
Wang, J. Y., Yamasaki, S., Takeuchi, K., et al. (1989). Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin, Gastroenterology 96, 393–402.
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Amagase, K., Okabe, S. Acetic acid ulcers: a new method for producing solitary chronic ulcers in rat stomachs by intraluminal application of acetic acid solution. Inflammopharmacology 10, 385–389 (2002). https://doi.org/10.1163/156856002321544855
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DOI: https://doi.org/10.1163/156856002321544855