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Melting of dsDNA attached with AuNPs

  • Regular Article - Soft Matter
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Abstract

DNA-linked gold nanoparticles (DNA-AuNPs) are combined nanomaterials that contain the optical and electronic properties of AuNPs with the unique functions of DNA. These hybrid systems are used in various nanobiotechnology, medical, and pharmaceutical sciences (Löwe et al. in FEBS J 287(23):5039, 2020; Speer et al. in Annu Rev Biophys 51:267, 2022). In recent years, there has been an increasing interest in studying the behavior of DNA-AuNPs in the presence of molecular solvents. In the present work, we study the thermal melting of DNA-linked gold nanoparticles (DNA-AuNP). In the first part of the study, we find the melting profile of short heterogeneous DNA-linked AuNP in the presence of solvent in the solution. We also study the effect of the location of the gold nanoparticle attached to the DNA molecule. In this case, we move the location of the AuNP from one end to the other. We found that while the melting temperature is susceptible to the location of the AuNP when it is near the ends, there is a region in the middle section of the chain where the melting temperature remains constant.

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The data that support the findings of this study are available upon reasonable request from the authors.

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Acknowledgements

We acknowledge the financial support from the Science and Engineering Research Board (SERB), New Delhi.

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  1. BITS-Pilani, Pilani Campus, 333031, Pilani, India

    Neha Mathur & Navin Singh

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  1. Neha Mathur
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  2. Navin Singh
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All authors contributed equally to the paper.

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Correspondence to Neha Mathur.

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Mathur, N., Singh, N. Melting of dsDNA attached with AuNPs. Eur. Phys. J. E 46, 58 (2023). https://doi.org/10.1140/epje/s10189-023-00318-2

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