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X-ray photoabsorption-induced processes within protonated rifamycin sodium salts in the gas phase

  • Regular Article - Molecular Physics and Chemical Physics
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Abstract

Up to now, the response of antibiotics upon ionizing radiation has been very scarcely reported. Here, we present the results of X-ray photoabsorption experiments on isolated rifamycin, a broad-range antibiotic against Gram-positive and Gram-negative bacteria. A mass spectrometer has been coupled to a synchrotron beamline to analyze cationic products of photoabsorption on protonated rifamycin dimer and monomer sodium salts. Absorption of a single photon in the 100–300eV energy range leads to ionization of the molecular system, followed by vibrational energy deposition and subsequent inter- and/or intramolecular fragmentation. Interestingly, we observe a proton transfer from sodiated rifamycin to rifamycin, a widely observed process in ionized molecular systems in the gas phase. Moreover, we show that another charge-transfer process occurs in both dimer and monomer: intramolecular sodium transfer, which has not been reported yet, to the best of our knowledge.

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Data Availability Statement

This manuscript has no associated data or the data will not be deposited. [Authors’ comment: The data will not be deposited because we could not find a suitable recommended repository for X-ray photoabsorption mass spectra of biomolecular systems.]

Notes

  1. As stated in the experimental section, to spot background peaks for each photon energy, we record a mass spectrum with the photon beam on and the ESI off, and another mass spectrum with the beam off and the ESI on. We did not find any signal at m/z 416 in any of these spectra.

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Acknowledgements

Benoît Colsch is acknowledged for fruitful discussion. This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 730872. M. Abdelmouleh is grateful to the PSIME doctoral school (Normandie Université, Caen) for funding a mission in Berlin.

Author information

Authors and Affiliations

  1. CIMAP UMR 6252 (CEA/CNRS/ENSICAEN/Université de Caen Normandie), Boulevard Becquerel, 14070, Caen Cedex 5, France

    Marwa Abdelmouleh, Andrea Espinosa Rodriguez, Juliette Leroux, Pinelopi Christodoulou & Jean-Christophe Poully

  2. Grupo de Física Nuclear, Dpto. de Estructura de la Materia, Física Térmica y Electrónica, Facultad de CC Físicas, GFN-UCM, Avda. Complutense, s/n, 28040, Madrid, Spain

    Andrea Espinosa Rodriguez

  3. Faculty of Biomedical Engineering, Czech Technical University in Prague, nám. Sítná 3105, 272 01, Kladno 2, Prague, Czech Republic

    Pinelopi Christodoulou

  4. Université de Caen Normandie, Plateforme PROTEOGEN, SF 4206 ICORE, Esplanade de la paix, 14032, Caen, France

    Benoît Bernay

  5. Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands

    Thomas Schlathölter

Authors
  1. Marwa Abdelmouleh
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  2. Andrea Espinosa Rodriguez
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  3. Juliette Leroux
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  4. Pinelopi Christodoulou
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  5. Benoît Bernay
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  6. Thomas Schlathölter
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  7. Jean-Christophe Poully
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Contributions

TS designed and built the experimental setup, and JCP wrote the proposal for obtaining the beamtime. The measurements were performed by MA, AER, BB and JCP. AER, JL, PC and JCP did the extensive data analysis of the results. JCP wrote the manuscript, and all authors read it and improved it thanks to their comments.

Corresponding author

Correspondence to Jean-Christophe Poully.

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Abdelmouleh, M., Espinosa Rodriguez, A., Leroux, J. et al. X-ray photoabsorption-induced processes within protonated rifamycin sodium salts in the gas phase. Eur. Phys. J. D 75, 74 (2021). https://doi.org/10.1140/epjd/s10053-021-00092-w

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  • DOI: https://doi.org/10.1140/epjd/s10053-021-00092-w

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