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Overview of recent advances in treatment planning for ion beam radiotherapy

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Abstract

To achieve practical calculations of dose delivery in ion beam radiotherapy, the physical models of beam propagation need to be properly implemented and supplemented by models describing the complex mechanisms of radiation damage in the biological tissues. TRiP98 is the first and most advanced treatment planning system for particles, in which physical and biological models have been incorporated to develop a clinically applicable tool for dose optimization and delivery. We report our recent advances in TRiP98 code development, in particular towards hypoxia-driven and multi-modal dose optimization. We also discuss the present needs and possible extensions of our models for which input from nanoscale physics is required.

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Authors and Affiliations

  1. Biophysics DepartmentGSI Helmholtzzentrum für Schwerionenforschung, Planckstr. 1, 64291, Darmstadt, Germany

    Michael Krämer, Emanuele Scifoni, Frederike Schmitz, Olga Sokol & Marco Durante

  2. University Heidelberg, Seminarstrasse 2, 69117, Heidelberg, Germany

    Frederike Schmitz

  3. Technical University Darmstadt, Hochschulstr. 6, 64289, Darmstadt, Germany

    Marco Durante

  4. Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438, Frankfurt am Main, Germany

    Marco Durante

Authors
  1. Michael Krämer
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  2. Emanuele Scifoni
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  3. Frederike Schmitz
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  4. Olga Sokol
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  5. Marco Durante
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Correspondence to Michael Krämer.

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Krämer, M., Scifoni, E., Schmitz, F. et al. Overview of recent advances in treatment planning for ion beam radiotherapy. Eur. Phys. J. D 68, 306 (2014). https://doi.org/10.1140/epjd/e2014-40843-x

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  • DOI: https://doi.org/10.1140/epjd/e2014-40843-x

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