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Thermodynamics and Kinetics of the Reaction between Pyridoxal-5-Phosphate and Hydrazides of 2-Methylfuran-3-Carboxylic and Thiophene-3-Carboxylic Acids in an Aqueous Solution

  • CHEMICAL THERMODYNAMICS AND THERMOCHEMISTRY
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Abstract

The stability constants of pyridoxal-5-phosphate hydrazones formed with 2-methylfuran-3-carbohydrazide and thiophene-3-carbohydrazide in an aqueous solution at pH 1.9, 6.6, 7.0, and 7.4 are determined via spectrophotometry. The kinetics of the processes of formation and hydrolysis of the Schiff bases are studied, and the constant of the direct and reverse reactions are calculated from the electronic absorption spectra. The stability constants of the Schiff bases are calculated from their ratio. The thermodynamic parameters of the reaction of formation (log K, ΔH, and TΔS) of both hydrazones at pH 6.6 are determined via calorimetry. The reasons for the differences between the equilibrium constants calculated from the data of spectrophotometric and kinetic experiments are discussed, and the reliability of the obtained results is analyzed.

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ACKNOWLEDGMENTS

This work was performed at the Institute of Thermodynamics and Kinetics of Chemical Processes, Ivanovo State University of Chemistry and Technology. It was supported by the Russian Foundation for Basic Research, project 16-33-60017; by the RF Presidential Council on Grants, project 14.Z56.18.877-MK, and by RF Ministry of Science and Higher Education, project 4.7305.2017/8.9. Our calorimetric experiments were performed on equipment at the shared resource center of the Ivanovo State University of Chemistry and Technology.

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  1. Ivanovo State University of Chemistry and Technology, 153000, Ivanovo, Russia

    G. A. Gamov, M. N. Zavalishin, D. N. Kabirov, T. R. Usacheva & V. A. Sharnin

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  1. G. A. Gamov
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  2. M. N. Zavalishin
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  3. D. N. Kabirov
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  4. T. R. Usacheva
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  5. V. A. Sharnin
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Correspondence to G. A. Gamov.

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Translated by E. Boltukhina

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Gamov, G.A., Zavalishin, M.N., Kabirov, D.N. et al. Thermodynamics and Kinetics of the Reaction between Pyridoxal-5-Phosphate and Hydrazides of 2-Methylfuran-3-Carboxylic and Thiophene-3-Carboxylic Acids in an Aqueous Solution. Russ. J. Phys. Chem. 93, 192–197 (2019). https://doi.org/10.1134/S0036024419020110

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