Biology Bulletin Reviews

, Volume 8, Issue 2, pp 114–123 | Cite as

Specific Features of Apoptotic Signaling Regulation in Cells Infected with Cytomegalovirus and Epstein–Barr Virus

  • N. A. Sakharnov
  • O. V. Utkin
  • D. I. Knyazev
  • E. N. Filatova
  • V. D. Tsvetkova
Article

Abstract

A large proportion of global population is infected with lymphotropic herpesviruses—cytomegalovirus (CMV) and Epstein–Barr virus (EBV). The products of CMV and EBV gene expression influence various elements of the apoptosis signaling pathways in infected cells and result in successful virus persistence. Some specific features in the interaction of CMV and EBV proteins and RNA transcripts with cellular proteins of apoptosis signaling pathways are considered. The review focuses on the structural and functional elements of the apoptosis-associated signaling pathways that are affected by these viruses.

Keywords

cytomegalovirus Epstein–Barr virus apoptosis signaling pathways programmed cell death 

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© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • N. A. Sakharnov
    • 1
  • O. V. Utkin
    • 1
    • 2
  • D. I. Knyazev
    • 1
  • E. N. Filatova
    • 1
  • V. D. Tsvetkova
    • 1
  1. 1.Blokhina Institute of Epidemiology and MicrobiologyFederal Service on Surveillance for Consumer Rights Protection and Human WelfareNizhny NovgorodRussia
  2. 2.Nizhny Novgorod State Medical AcademyMinistry of Public Health of the Russian FederationNizhny NovgorodRussia

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