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Specific Features of Apoptotic Signaling Regulation in Cells Infected with Cytomegalovirus and Epstein–Barr Virus

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Abstract

A large proportion of global population is infected with lymphotropic herpesviruses—cytomegalovirus (CMV) and Epstein–Barr virus (EBV). The products of CMV and EBV gene expression influence various elements of the apoptosis signaling pathways in infected cells and result in successful virus persistence. Some specific features in the interaction of CMV and EBV proteins and RNA transcripts with cellular proteins of apoptosis signaling pathways are considered. The review focuses on the structural and functional elements of the apoptosis-associated signaling pathways that are affected by these viruses.

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Authors and Affiliations

  1. Blokhina Institute of Epidemiology and Microbiology, Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russia

    N. A. Sakharnov, O. V. Utkin, D. I. Knyazev, E. N. Filatova & V. D. Tsvetkova

  2. Nizhny Novgorod State Medical Academy, Ministry of Public Health of the Russian Federation, Nizhny Novgorod, Russia

    O. V. Utkin

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  1. N. A. Sakharnov
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  2. O. V. Utkin
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  3. D. I. Knyazev
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  4. E. N. Filatova
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  5. V. D. Tsvetkova
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Correspondence to N. A. Sakharnov.

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Original Russian Text © N.A. Sakharnov, O.V. Utkin, D.I. Knyazev, E.N. Filatova, V.D. Tsvetkova, 2017, published in Uspekhi Sovremennoi Biologii, 2017, Vol. 137, No. 4, pp. 387–397.

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Sakharnov, N.A., Utkin, O.V., Knyazev, D.I. et al. Specific Features of Apoptotic Signaling Regulation in Cells Infected with Cytomegalovirus and Epstein–Barr Virus. Biol Bull Rev 8, 114–123 (2018). https://doi.org/10.1134/S207908641802007X

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  • DOI: https://doi.org/10.1134/S207908641802007X

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