Abstract
The signs of destabilization in rats selected for catatonia were studied on the organism level. A unique strain of animals with genetic catatonia (GC) consisting of rats selected for their long-term passivedefensive freezing response was used for the study. The aim of the present study was to detect the signs of destabilization in the behavioral and somatovegetative parameters of GC rats that appeared in response to their selection. The destabilization was manifested as aggressive attitudes in rats towards humans, as became apparent from the “glove” test. A lower content of corticosterone was revealed in the fecal boli of GC rats when they were in a calm state and it increased after the rats were held in human hands. The altered metabolic indices, which were expressed in the lower levels of carbohydrates (glucose) and lipids (triglycerides), included a decrease in their stored energy. However, the strains studied did not differ in the concentration of insulin, which affects the transport of glucose through the cell membrane. There were no differences between Wistar and GC rats in the cholesterol level either; this lipid is important for both energy and constructive metabolism. A side effect of selection for catatonia was a deterioration of the pelage state in GC rats. Reduced body weight in both neonates and adult GC rats compared to those in the parental Wistar population was observed as the overall physical condition of catatonic rats. All these changes indicate the modification of behavioral and somatovegetative patterns and intensification of the passive-defensive component of selection in GC rats.
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Original Russian Text © T.A. Alekhina, N.A. Palchikova, R.V. Kozhemyakina, O.I. Prokudina, 2016, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2016, Vol. 20, No. 1, pp. 28–33.
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Alekhina, T.A., Palchikova, N.A., Kozhemyakina, R.V. et al. The signs of destabilization in behavioral and somatovegetative parameters in rats selected for catatonia. Russ J Genet Appl Res 6, 798–803 (2016). https://doi.org/10.1134/S2079059716080025
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DOI: https://doi.org/10.1134/S2079059716080025