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The intron-containing transcript: an evolutionarily conserved characteristic of the genes orthologous to nxf1 (Nuclear Export Factor 1)

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Russian Journal of Genetics: Applied Research

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Abstract

The function of the nxf1 (Nuclear Export Factor 1) gene is the nuclear-cytoplasmic transport of most mRNAs. A characteristic feature of the nxf1 genes in animals belonging to different taxonomic groups is existence of an alternative transcript with a homologous intron referred to as a cassette intron. The following databases were used: GenBank (http://www.ncbi.nlm.nih.gov/); FlyBase (http://flybase.org/); and UCSC Genome (http://genome.ucsc.edu). To build secondary structures of nucleotide sequences we used a UNAFold v3.8 suite (http://mfold.rna.albany.edu/). The nxf1 cassette introns form characteristic secondary structures. The paper discusses the possible functional significance of the intron-retaining transcripts of the nxf1 genes.

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  1. St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, 199034, Russia

    L. A. Mamon, S. F. Kliver, A. O. Prosovskaya, V. R. Ginanova & Ye. V. Golubkova

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  1. L. A. Mamon
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  2. S. F. Kliver
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  3. A. O. Prosovskaya
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  4. V. R. Ginanova
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  5. Ye. V. Golubkova
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Correspondence to L. A. Mamon.

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Original Russian Text © L.A. Mamon, S.F. Kliver, A.O. Prosovskaya, V.R. Ginanova, Ye.V. Golubkova, 2013, published in Ekologicheskaya Genetika, 2013, Vol. 11, No. 3, pp. 3–13.

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Mamon, L.A., Kliver, S.F., Prosovskaya, A.O. et al. The intron-containing transcript: an evolutionarily conserved characteristic of the genes orthologous to nxf1 (Nuclear Export Factor 1). Russ J Genet Appl Res 4, 434–443 (2014). https://doi.org/10.1134/S2079059714050104

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