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LIM-kinase 1 in regulation of cognitive and locomotor functions of Drosophila melanogaster

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Russian Journal of Genetics: Applied Research

Abstract

LIM-kinase 1 is a key enzyme of actin remodeling, which is necessary for synaptic plasticity during learning and memory formation. The deletion of the limk1 leads to the development of Williams’s syndrome accompanied by cognitive impairments and motor dysfunction, which is referred to as cytoskeleton diseases, cofilin pathologies. Cofilin pathologies are characterized by the formation of cofilin-actin complexes in neurons, which disrupt vesicular transport and identify early stages of dementia. In the present article, we briefly reviewed the data on the role of the LIMK1 functioning in communicative sound production during courtship behavior, learning acquisition, and memory formation.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. N. Kaminskaya

  2. St. Petersburg State University, St. Petersburg, Russia

    A. N. Kaminskaya & A. V. Medvedeva

  3. Pavlov Institute of Physiology, St. Petersburg, Russia

    A. V. Medvedeva

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  1. A. N. Kaminskaya
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Correspondence to A. N. Kaminskaya.

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Original Russian Text © A.N. Kaminskaya, A.V. Medvedeva, 2013, published in Ekologicheskaya Genetika, 2013, Vol. 11, No. 3, pp. 63–78.

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Kaminskaya, A.N., Medvedeva, A.V. LIM-kinase 1 in regulation of cognitive and locomotor functions of Drosophila melanogaster . Russ J Genet Appl Res 4, 466–477 (2014). https://doi.org/10.1134/S2079059714050050

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