Abstract
We used high-density microarrays to investigate polymorphisms in more than 1500 genetic markers, associated with risks for a wide range of multifactorial diseases. We identified a set of 31 genes, whose products are associated with the risk of preeclampsia, based on the functional annotations of the genes in the bioinformatics resources, DAVID and GFINDer. We determined the population frequencies of alleles and genotypes for these 31 genes: ACE, ADIPOQ, ADRB2, ADRB3, AGT, APOE, CRP, CTLA4, CYP1A1, CYP2D6, CYP2E1, EDNRA, ESR1, ESR2, F5, HLA-DQA1, HSPA1A, IL1A, IL1RN, IL6, IL6R, LEP, LEPR, LPL, MTHFR, NOS3, PON1, TAP2, TGFB1, TNFA, and VEGFA. Comparative analysis between the Russian and Central European study groups revealed statistically significant differences in the allelic and genotypic frequencies for six genes: CYP2D6, CTLA4, AGT, NOS3, PON1 and ADRB2. The obtained data points to a similar genetic basis for the risk of vascular diseases, associated with pregnancy, in the Russian and European populations, and these results can be used for further genetic and epidemiological studies.
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Original Russian Text © A.S. Glotov, Ye.S. Vashukova, O.S. Glotov, Yu.A. Nasykhova, A.M. Mazur, R.V. Kurilov, V.M. Pekhov, Ye.E. Khrameyeva, T.E. Ivashchenko, V.S. Baranov, 2013, published in Ekologicheskaya Genetika, 2013, Vol. 11, No. 1, pp. 91–100.
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Glotov, A.S., Vashukova, Y.S., Glotov, O.S. et al. Study of the population frequencies of gene polymorphisms, associated with preeclampsia. Russ J Genet Appl Res 4, 388–396 (2014). https://doi.org/10.1134/S2079059714050049
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DOI: https://doi.org/10.1134/S2079059714050049