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Overexpression of genes encoding asparagine-glutamine-rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae

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Russian Journal of Genetics: Applied Research

Abstract

We previously conducted a search for genes whose overexpression causes nonsense suppression in Saccharomyces cerevisiae with a background of modified expression of Sup35 variants. In this study, we analyzed the influence of genes encoding asparagine-glutamine-rich transcriptional factors on this process. We demonstrated that the overexpression of ABF1, GLN3, FKH2, MCM1, MOT3, and REB1 affects nonsense suppression in S. cerevisiae. The data obtained highlight the interrelation between the fundamental processes of transcription and translation in the living cell.

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Authors and Affiliations

  1. Department of Genetics and Biotechnology, St. Petersburg State University, St. Petersburg, Russia

    A. A. Nizhnikov, A. M. Kondrashkina, K. S. Antonets & A. P. Galkin

  2. St. Petersburg Branch, N.I. Vavilov Institute of General Genetics of the RAS, St. Petersburg, Russia

    A. A. Nizhnikov & A. P. Galkin

Authors
  1. A. A. Nizhnikov
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  2. A. M. Kondrashkina
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  3. K. S. Antonets
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  4. A. P. Galkin
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Correspondence to A. A. Nizhnikov.

Additional information

Published in Russian in Ekologicheskaya Genetika, 2013, Vol. 11, No. 1, pp. 49–58.

The article was translated by the authors.

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Nizhnikov, A.A., Kondrashkina, A.M., Antonets, K.S. et al. Overexpression of genes encoding asparagine-glutamine-rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae . Russ J Genet Appl Res 4, 122–130 (2014). https://doi.org/10.1134/S2079059714020051

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  • DOI: https://doi.org/10.1134/S2079059714020051

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