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Drosophila melanogaster genome: Correlation of chromatin state with splicing and transcription regulation

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Russian Journal of Genetics: Applied Research

Abstract

A number of chromatin characteristics of exon regions have been revealed by analysis of chromatin modifications. The distribution of histone modifications in exon regions greatly varies among cell types. The correlation of the rate of alternative splicing with a certain chromatin type has been analyzed, and its most characteristic types have been identified. The distribution of chromatin labels in the DScam gene, which produces an enormous number of transcripts, assessed at 38000, is presented as an example. It is concluded that this gene undergoes integrated regulation by the chromatin state at the levels of domains and exons.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    V. N. Babenko

  2. Novosibirsk State University, Novosibirsk, Russia

    V. F. Matvienko

  3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    I. A. Zykov

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  1. V. N. Babenko
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  2. V. F. Matvienko
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  3. I. A. Zykov
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Correspondence to V. N. Babenko.

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Original Russian Text © V.N. Babenko, V.F. Matvienko, I.A. Zykov, 2011, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2011, Vol. 15, No. 3, pp. 579–594.

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Babenko, V.N., Matvienko, V.F. & Zykov, I.A. Drosophila melanogaster genome: Correlation of chromatin state with splicing and transcription regulation. Russ J Genet Appl Res 2, 85–96 (2012). https://doi.org/10.1134/S2079059712010029

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  • DOI: https://doi.org/10.1134/S2079059712010029

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