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Genetics and epigenetics of syntropic diseases

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Russian Journal of Genetics: Applied Research

Abstract

Genetic components are involved in the etiology of the overwhelming majority of the most common complex human diseases. Three methodological approaches have been used successfully for the identification of genetic factors predisposed to common human diseases: linkage analysis, candidate gene association studies (GASs), and genome-wide association scans (GWASs). The structural features of many genes make a small but significant contribution to the overall risk of common diseases. Syntropy of related diseases is determined by the participation in their pathogenesis of the functional polymorphisms of genes controlling the same metabolic pathways. Nonrandom combination of different diseases in the same patients is determined by common epigenetic mechanisms in expression control of different “gene nets.”

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Authors and Affiliations

  1. St. Petersburg State Pediatric Medical Academy, St. Petersburg, Russia

    V. N. Gorbunova

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  1. V. N. Gorbunova
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Original Russian Text © V.N. Gorbunova, 2010, published in Ekologicheskaya Genetika, 2010, Vol. 8, No. 4, pp. 39–43.

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Gorbunova, V.N. Genetics and epigenetics of syntropic diseases. Russ J Genet Appl Res 1, 431–435 (2011). https://doi.org/10.1134/S2079059711050078

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  • DOI: https://doi.org/10.1134/S2079059711050078

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