Abstract
Cognitive-emotional signs of aging were studied in F1 (C57BL/6 × DBA/2) mice at the ages of 3, 7, and 14 months. It was found that memory-trace fixation, the first appearance of the minimized variant of the solution of the problem (the minimized route, MR), and the rate of its subsequent retrieval in the experiment, as well as the breadth of the emotional repertoire in all animals, did not depend on age. The greatest age-related differences were associated with the ability of mice to reproduce MR sustainably. It turned out that such an implementation was possible only if it was preceded by a period of mistakes. Moreover, the older the animal was, the higher was the number of unsuccessful attempts and levels of provoked stressful and neurotic reactions required for food acquisition. The data indicates that the activating effects of negative emotional arousal are a mechanism that contributes to the achievement of the level of excitation required for the realization of the dominant state upon a weak energy state of the central nervous system.
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REFERENCES
Anokhin, P.K., Biologiya i neirofiziologiya uslovnogo refleksa (Biology and Neurophysiology of Conditioned Reflex), Moscow: Meditsina, 1968.
Zakharov, V.V., Savushkina, I.Yu., Mkhitaryan, E.A., et al., Age-related dynamics of cognitive functions in persons aged 50–85 years, Adv. Gerontol., 2018, vol. 8, no. 1, pp. 41–46.
Kondashevskaya, M.V., Diatroptov, M.E., Ponamorenko, E.A., et al., Specific adaptive reactions of immune and endocrine system in mouse males of F1 (C57BL/6 × DBA/2) during food deprivation, cognitive tension and in conditions of the enriched environment, Immunologiya, 2015, vol. 36, no. 4, pp. 206–210.
Nikolskaya, K.A., Tolchennikova, V.V., and Kondashevskaya, M.V., Psychophysiological signs of aging in mice F1 (C57BL/6 × DBA/2), Adv. Gerontol., 2020, vol. 10, no. 2, pp. 115–120.
Soloviev, A.G., Popov, V.V., and Novikova, I.A., Diagnosis of disorders of the emotional sphere in older persons, Adv. Gerontol., 2016, vol. 6, no. 3, pp. 249–259.
Frol’kis, V.V., Starenie i uvelichenie prodolzhitel’nosti zhizni (Aging and Lifespan Prolongation), Leningrad: Nauka, 1988.
Cruciani, F., Berardi, A., Cabib, S., et al., Positive and negative emotional arousal increases duration of memory traces: common and independent mechanisms, Front. Behav. Neurosci., 2011, vol. 5, p. 86. https://doi.org/10.3389/fnbeh.2011.00086
Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes, Off. J. Eur. Union, 2010, vol. 53, pp. 33–80. https://doi.org/10.3000/17252555.L_2010.276.eng
Serkova, V.V. and Nikolskaya, K.A., Effects of spatial imprinting on the development of the cognitive process in adult animals, Ross. Fiziol. Zh. im. I.M. Sechenova, 2013, vol. 99, no. 12, pp. 1366–1377. PMID 25464767.
Shin, A.C., Zheng, H., and Berthoud, H.-R., An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat, Physiol. Behav., 2009, vol. 97, no. 5, pp. 572–580.
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The study was supported within the framework of the state assignment under the contract 11-1-16, No. TsITIS, АААА-А-16-116021660055-1.
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Statement on the welfare of animals. All procedures were performed in compliance with the ethical standards and rules contained in Directive 2010/63/EU on the use of experimental animals [8].
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Translated by A. Deryabina
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Nikolskaya, K.A., Kondashevskaya, M.V. Cognitive-Emotional Signs of Aging in F1 Mice (C57BL/6 × DBA/2). Adv Gerontol 11, 158–163 (2021). https://doi.org/10.1134/S2079057021020090
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DOI: https://doi.org/10.1134/S2079057021020090